The transmembrane migration method has permitted quantification of the effect of drugs on human sperm motility. Calcium ionophores and calcium antagonists have paradoxical effects on motility depending on the stage of sperm maturity. Drugs with membrane stabilizing properties inhibit sperm motility. Propranolol, for example, has been shown to have contraceptive activity when administered intra-...

Fifty patients with non-cirrhotic portal fibrosis who were admitted to hospital because of upper gastrointestinal bleeding were randomly assigned to treatment with either oral propranolol given in doses that reduced the resting pulse rate by 25% (25 patients) or with a placebo (25 patients). One year after the start of the study 20 patients in the propranolol group and five patients in the plac...

InnoPran XL (propranolol hydrochloride) is a nonselective, beta-adrenergic receptorblocking agent for oral administration, available as an extended release product. InnoPran XL is available as 80 mg and 120 mg capsules which contain sustained-release beads. Each of the beads contains propranolol hydrochloride and is coated with dual membranes. These membranes are designed to retard release of p...

purpose To compare our results with intralesional corticosteroids (IC) injections to those with oral propranolol (P) medication in children with a peri-orbital infantile hemangioma (IH). design Retrospective comparison of two treatment groups. participants Children diagnosed with IH and treated with IC (n = 29) or P (n = 14) by the multidisciplinary task force of the Academic Medical Center in ...

1. The effect of a single oral dose of propranolol on the ventilatory response to hypercapnia has been studied in five healthy subjects. 2. Propranolol produced a small but significant reduction in the slope of the ventilation/end-tidal PCO2 regression line. 3. Propranolol did not significantly change vital capacity or forced expiratory volume in 1 s.

Antecedentes: los hemangiomas infantiles son tumores vasculares benignos más frecuentes en la infancia, siendo su localización habitual cabeza y el cuello, representando 50 % de las masas que afectan a glándula parótida. Debido al rápido crecimiento expansivo estas lesiones, pueden aparecer complicaciones significativas, como pérdida función del órgano o desfiguración permanente, por lo interve...

A 6-week-old girl was referred for management of a large left orbital and periorbital capillary hemangioma (Figure 1, Figure 2, Figure 3 and Figure 4; available at http://aaojournal.org). The neoplasm had been present since birth and getting progressively larger with resultant occlusive, anisometropic, and strabismic amblyopia of the left eye. She had received 1 intralesional steroid injection ...

The objective of this study is to describe the initial use of propranolol as the sole treatment for focal infantile airway hemangiomas, and to report on available literature describing the use of propranolol for airway lesions. This retrospective case series was carried out at a tertiary pediatric medical center. We obtained the following results: two children demonstrated significant response ...

      An oral suspension could a suitable dosage form for the geriatric patients. The calcium alginate coated ion exchange resinate of propranolol hydrochloride were prepared using Amberlite IR-120 by solvent evaporation. Microcapsules of propranolol hydrochloride resinate were prepared by solvent evaporation technique,the suspensions were prepared by using deionised water as the vehicle. Methy...

Plasma propranolol levels associated with reductions in endogenous and exogenous cardiac beta-stimulation were determined in normal people. The levels associated with a given degree of blockade of exercise-induced tachycardia were about three times greater after intravenous administration than after oral administration. This shows that an active metabolite of propranolol is formed only after th...