Introduction: There has been a subtle yet steady augmentation in oral submucous fibrosis, a potentially malignant disorder, both in India and across the world. Various efforts are being made to develop dependable and non-invasive biochemical tests for the early detection and diagnosis of this disorder. Of late, the role of specific salivary biomarkers has been studied comprehensively. Methods: ...

Oral submucous fibrosis is a chronic insidious disease and a well-recognized potentially malignant condition of the oral cavity. It is a collagen related disorder associated with betel quid chewing and characterized by progressive hyalinization of the lamina propria. Objectives: It is traditionally held that in oral submucous fibrosis the hyalinization process starts from the lamina propria and...

Precancerous lesions of oral mucosa, known as potentially malignant disorders in recent years, are consists a group diseases, which should be diagnosed the early stage. Oral leukoplakia, submucous fibrosis, and erythroplakia most common mucosal diseases that have very high transformation rate.

background: syndecan‑1 is abundant in normal tissues and reduced in squamous cell carcinomas. leukoplakia and oral submucous fibrosis (osf) are oral pre‑cancerous disorders that have potential for malignant transformation. the aim of this study was to evaluate the expression of syndecan‑1 in leukoplakia and osf and to identify its role as a reliable marker for predicting malignant changes. mate...

OBJECTIVES The objective of this study was to identify salivary and serum concentrations of interleukin (IL)-8, IL-6, and tumor necrosis factor alpha (TNF-α) in patients with oral lichen planus, oral leukoplakia, oral submucous fibrosis, and healthy controls. MATERIALS AND METHODS Patients selected included 54 oral lichen planus (41 to 65 years), 50 oral leukoplakia (42 to 65 years), 51 oral ...

In the present work, stress was given for improvised local action of the drug with the addition of mucoadhesive polymer in the formulation. Oral mucoadhesive semi solid gel was prepared for the treatment of oral sub mucous fibrosis, which provides effect for extended periods of time. Curcumin was taken as a model drug as it exhibits profound antitumeric & antimutogenic activity. The semisolid p...

The pharmacokinetics of the commonly used contraceptive steroids ethinyloestradiol and levonorgestrel were investigated after oral and intravenous administration in six women with cystic fibrosis. The results were compared with data obtained from healthy women of similar age. The total body clearance of ethinyloestradiol was significantly higher in the patients with cystic fibrosis (0.61 (SD 0....

Oral submucous fibrosis is a chronic, insidious disease affecting the oral cavity and sometimes pharynx. Although occasionally preceded and/or associated with vesicle formation, is always associated with juxtaepithelial inflammatory reaction followed by fibro elastic changes in lamina propria with epithelial atrophy leading to stiffness of oral cavity leading to trismus and inability to eat. Al...

Oral sub mucous fibrosis is a crippling disease of mouth with high malignant potential that has high prevalence rate in India and South East Asia. The treatment of patients with oral submucous fibrosis depends on the degree of clinical involvement. If the disease is detected at a very early stage, cessation of the habit is sufficient. Medical treatment is symptomatic and predominantly aimed at ...