The effect of extirpation of the submandibular glands, an exocrine organ for epidermal growth factor/urogastrone (EGF/URO), and the effect of oral administration of synthetic human (EGF/URO) on healing of chronic gastric ulcers in rats has been investigated. Removal of the submandibular glands delayed healing of chronic gastric ulcers when examined after 50, 100, and 200 days. Oral administrati...

Background and aim: Pemphigus vulgaris (PV) is an autoimmune disorder that can clinically manifest as oral mucosal ulcers. Several researchers believe that the level of female sex hormones such as estrogen and progesterone could be effective in the pathogenesis and growth of lesions such as desquamative gingivitis. Studies related to oral ulcers have revealed contradictory results regarding the...

HIV-related oral conditions occur in a large proportion of patients, and frequently are misdiagnosed or inadequately treated. Dental expertise is necessary for appropriate management of oral manifestations of HIV infection or AIDS, but many patients do not receive adequate dental care. Common or notable HIV-related oral conditions include xerostomia, candidiasis, oral hairy leukoplakia, periodo...

Patients with prolonged neutropenia are at risk for a variety of complications and infections including the development of mucositis and oral ulcers. The changes in oral flora during chemotherapy and its effects on the development of infections of the oral cavity have been studied with inconsistent results. However, there is evidence that supports the colonization of gram negative rods in patie...

Some conditions that can mimic canker sores include traumatic injury, autoimmune conditions, viral infections (such as herpes simplex and herpes zoster [shingles]), and most importantly, oral cancer. In addition, oral ulcers can be associated with a number of systemic conditions in which the oral ulcers represent only a small part of the underlying problem. A general rule of thumb recommended b...

A controlled trial of oral acyclovir in herpetic dendritic corneal ulcers was carried out on 31 patients. All patients received minimal wiping debridement of the ulcer, following which they were randomly allocated to receive either oral acyclovir or placebo for 7 days. At the end of treatment 67% of dendritic ulcers in patients receiving acyclovir had healed compared with 43% in placebo recipie...

Oral ulcerations are common lesions encountered in private practice. Oral ulcers can have a localised aetiology or be a manifestation of a variety of systemic conditions or disorders (see Table I). Appropriate management depends on the correct diagnosis, which at times can be difficult due to similar clinical features. The aetiology, diagnosis and management of the most common non-viral ulcerat...

Some conditions that can mimic canker sores include traumatic injury, autoimmune conditions, viral infections (such as herpes simplex and herpes zoster [shingles]), and most importantly, oral cancer. In addition, oral ulcers can be associated with a number of systemic conditions in which the oral ulcers represent only a small part of the underlying problem. A general rule of thumb recommended b...

Some conditions that can mimic canker sores include traumatic injury, autoimmune conditions, viral infections (such as herpes simplex and herpes zoster [shingles]), and most importantly, oral cancer. In addition, oral ulcers can be associated with a number of systemic conditions in which the oral ulcers represent only a small part of the underlying problem. A general rule of thumb recommended b...

INTRODUCTION Though oral aphthosis is common, it has a significant impact on the quality of life in the patients. It is the most common oral ulcerative condition encountered in clinical practice. This study describes the characteristics and patterns of oral aphthosis seen at a tertiary dermatological centre in Singapore, with emphasis in evaluating the management gaps and in identifying underly...