Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym" based reagents. It aims to demystify the process allowing the chemist to mak...

______________________________________________ Abstract: A major challenge in organic synthesis is the selective reaction of a functional group in the presence of others. This can be achieved by using an appropriate reagent, tuned to react exclusively at the desired centre. An alternate approach would be to use a single reagent, and to transmit from the outside the information as to where it sh...

Experimental and theoretical studies of metalated peroxides confirmed their unique properties as oxenoids (electrophilic oxidants) allowing for a highly selective and efficient oxidation processes of nucleophilic organometallic species. In this short review we present the most prominent examples of the application of this class of reagents towards organic synthesis.

C. W. Bowen and G. M. Bodner “Problem-Solving Processes Used by Graduate Students While Solving Tasks in Organic Synthesis,” International Journal of Science Education, vol. 13, no. 2, pp. 143-158, 1991. Organic synthesis is the branch of chemistry that deals with the step-by-step conversion of relatively simple starting materials into larger, more complicated, target molecules. Synthesis probl...

The use of flow chemistry techniques has flourished over the past decade, with the field expanding to include the use of copper flow reactors in bench-top organic synthesis in recent years. These reactors are available in a variety of forms and possess a number of advantages over their batch reaction counterparts, in terms of both safety and yield. This review will highlight the current researc...