Alzheimer’s disease is insidious progressive age related neurological disorder which leads to the loss of cognitive functions, memory processes and associated behavior. The role of environmental factor and genetic susceptibility in the etiology of Alzheimer’s disease has been reviewed in recent years. Organophosphates, a class of insecticide are widely used in the agriculture, home, garden, pub...

We have been developing non-traditional methods of the identification of pollutants, using various hydrobionts as biological objects and the study of the mechanism of toxic action of xenobiotics. The experiments were carried out with using of Daphnia magna. Daphnia magna is a Crustacean in the order of Cladocera. Experiments were performed with a 2-days old culture of Daphnia magna. The toxicit...

Synthetic Pyrethroids are synthetic analogs of naturally occurring pyrethrins, found in extract from Chrysanthemum flowers. They were launched as a replacement of highly toxic class of pesticides like DDT and Organophosphates in 1980s. Major success of pyrethroids lies in the low toxicity of them towards mammals as well as humans and due to which they have wide range of applications right from ...

Fertile White Leghorn chicken eggs were injected on the 10th day of incubation with 0, 1.50, or 2.00 p.p.m. Thimet and allowed to hatch. The following parameters were examined: hatchability, incidence of deformities, thyroid weight, thyroid histology, thyroid I uptake, and brain cholinesterase activity. As the Thimet dosage was increased, the hatchability decreased, and the incidence of deformi...

The baseline and residual activity of micro-encapsulated insecticides was assessed on a sandfly colony originating in the Jordan Valley, Israel. Lethal doses were calculated for formulations of the pyrethroids permethrin and cypermethrin and the organophosphates diazinon and chlorpyrifos. Cypermethrin was found to be more toxic than permethrin and chlorpyrifos was more toxic than diazinon. Acco...

Organophosphate pesticides exert their toxic effects by cholinesterase inhibition and the consequent prolongation of the undesirable effects of accumulation of acetylcholine. The signs of toxicity include tremors, convulsions, lachrymation, defecation etc. However, sustained cholinesterase inhibition through sustained administration of organophosphates would lead to the gradual disappearance of...