This review highlights the rapid evolution of the newly-developed class of palladium-catalyzed cross-coupling reactions of organosilicon compounds. A myriad of heteroatom-containing silicon moieties (silyl hydrides, siletanes, silanols, silyl ethers, orthosiliconates, di- and polysiloxanes and pyridylsilanes) undergo mild and stereospecific cross-coupling. The diversity of methods for introduct...

Laser flash photolysis of various organosilicon compounds such as aryl-, vinyl-, and alkynyldisilanes, silacyclobutanes and silacyclobutenes, and alpha-silylketenes and -diazomethanes leads to the formation of reactive silenes which can be detected directly in solution, allowing detailed studies of the kinetics and mechanisms of their reactions with nucleophiles. Over 30 transient silenes have ...

C a r b o n f u n c t i o n a l s i l a n e s b e a r i n g c o u m a r i n t y p e f u n c t i o n a l g r o u p s a r e o f i n t e r e s t d u e t o t h e i r p o t e n t i a l i m p o r t a n c e as p r e c u r s o r s i n c o s m e t i c i n d u s t r i e s . W e r e p o r t t h e s y n t h e s i s o f s o m e 4 o r g a n o s i l i c o n d e r i v a t i v e s o f 7 h y d r o x y c o u m a ...

The synthesis of α-aminosilanes by a highly enantio- and regioselective copper-catalyzed hydroamination of vinylsilanes is reported. The system employs Cu-DTBM-SEGPHOS as the catalyst, diethoxymethylsilane as the stoichiometric reductant, and O-benzoylhydroxylamines as the electrophilic nitrogen source. This hydroamination reaction is compatible with differentially substituted vinylsilanes, thu...

Enzymes that catalyze carbon-silicon bond formation are unknown in nature, despite the natural abundance of both elements. Such enzymes would expand the catalytic repertoire of biology, enabling living systems to access chemical space previously only open to synthetic chemistry. We have discovered that heme proteins catalyze the formation of organosilicon compounds under physiological condition...