Incidence and prevalence of owerweight and obesity have greatly increased over the past three decades in almost all countries around the world. This phenomenon is not easily explained by lifestyle changes in populations with very different initial habits. This has led to consider the influence of other factors, the so-called endocrine disruptors, and more specifically obesogens. This study revi...

Mechanisms of immunosuppression by organotins – apoptosis vs. proliferative arrest-Proefschrift Universiteit Utrecht. Met een samenvatting in het Nederlands. Con un riassunto in Italiano. CONTENTS Chapter 1 General Introduction 5 Chapter 2 Organotin-induced apoptosis as observed in vitro is not relevant for induction of thymus atrophy at antiproliferative doses Chapter 3 Organotin-induced apopt...

organotin compound that have at least one sn-c bond have wide commercial applications as pvc stabilizer, antifouling agent in paint and as agrochemicals. the general formula for organotin compounds is r4snx4 - n where r is normally alkyl or aryl groups and x=cl-, oh-, ch3coo- . if n=3, the compound has the highest toxicity, for example et3snoac has ld 50 4mg/kg ( rats ) and this is the most tox...

The polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and organotins were analyzed in mussels Mytilus galloprovincialis from polluted and unpolluted sites from Mokpo Bay, Korea. The total PAH's concentrations (10(-3)mgkg(-1)) measured by GC-MS were in the range from 31+/-23 to 1+/-1. Among the eight PAHs the predominant ones were fluoranthene, phenanthrene and pyrene and...

BACKGROUND Organotins are highly toxic and widely distributed environmental chemicals. Dibutyltin (DBT) is used as stabilizer in the production of polyvinyl chloride plastics, and it is also the major metabolite formed from tributyltin (TBT) in vivo. DBT is immunotoxic, however, the responsible targets remain to be defined. Due to the importance of glucocorticoids in immune-modulation, we inves...