نتایج جستجو برای: osteoclasts
تعداد نتایج: 6297 فیلتر نتایج به سال:
objective(s): salvia miltiorrhiza (sm) is a popular and classic herb in traditional chineses medicines. the objective is to confirm the effects of aqueous extract of s. miltiorrhiza (esm) and its main ingredient on the promotion of orthodontic tooth movement and healing of periodontal ligament in rat. materials and methods: male sprague-dawley rats (n= 150) were divided into five groups: model ...
Kajiya, Hiroshi, Fujio Okamoto, Hidefumi Fukushima, Keisuke Takada, and Koji Okabe. Mechanism and role of high-potassium-induced reduction of intracellular Ca2 concentration in rat osteoclasts. Am J Physiol Cell Physiol 285: C457–C466, 2003. First published April 9, 2003; 10.1152/ajpcell.00033.2003.—Osteoclasts are multinucleated, bone-resorbing cells that show structural and functional differe...
To elucidate the direct role and mechanism of FGFR1 signaling in the differentiation and activation of osteoclasts, we conditionally inactivated FGFR1 in bone marrow monocytes and mature osteoclasts of mice. Mice deficient in FGFR1 (Fgfr1(-/-)) exhibited misregulated bone remodeling with reduced osteoclast number and impaired osteoclast function. In vitro assay demonstrated that the number of t...
The actin cytoskeleton is essential for osteoclasts main function, bone resorption. Two different organizations of actin have been described in osteoclasts, the podosomes belt corresponding to numerous F-actin columns arranged at the cell periphery, and the sealing zone defined as a unique large band of actin. To compare the role of these two different actin organizations, we imaged osteoclasts...
BACKGROUND Osteoclasts are the body's sole bone resorbing cells. Cytokines produced by pro-inflammatory effector T-cells (T(EFF)) increase bone resorption by osteoclasts. Prolonged exposure to the T(EFF) produced cytokines leads to bone erosion diseases such as osteoporosis and rheumatoid arthritis. The crosstalk between T-cells and osteoclasts has been termed osteoimmunology. We have previousl...
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