One of the main health issues facing general practitioners in and gynecologists particular is ovarian tumors. Ovarian cancer second most prevalent malignancy female reproductive system fifth leading cause cancer-related death women. The majority instances are discovered when disease has already progressed even though early neoplasms benign which emphasizes importance detection.  &nbsp...

INTRODUCTION Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and malignant ovarian neoplasm was evaluated. In addition, immunostaining was related to prognostic fa...

BACKGROUND Epithelial ovarian neoplasms are an important cause of morbidity and mortality in women. The surgical management of ovarian neoplasms depends on their correct categorization as benign, borderline or malignant. This study was undertaken to evaluate the accuracy of intra-operative frozen section in the diagnosis of various categories of ovarian neoplasms. METHODS Intraoperative froze...

The expression of Ca antigen in ovarian epithelial tumours has been studied by an immunohistochemical technique using the Ca 1 monoclonal antibody. The antigen was found to be present in some examples of each of the histological subtypes of ovarian epithelial neoplasms and was detected in benign, borderline and malignant tumours. It is concluded that the presence of Ca antigen is of no discrimi...

Ovarian sex cord-stromal tumors are relatively infrequent neoplasms that account for approximately 8% of all primary ovarian neoplasm. Sex cord-stromal tumors of the ovary include granulosa cell tumors, fibrothecomas, Sertoli-Leydigcell tumors, steroid cell tumors, and sclerosing stromal tumors (SST). Sclerosing stromal tumors account for 2% to 6% of ovarian stromal tumors. Despite the rarity o...

OBJECTIVES The objectives were to determine the time course for ovarian failure in rats caused by 4-vinylcyclohexene diepoxide (VCD) and develop a model for ovarian cancer in which ovarian neoplasms were chemically induced in an animal that was follicle depleted, but retained residual ovarian tissue. METHODS Initially, female Fisher 344 rats were treated with VCD (to induce ovarian failure) o...

Non-epithelial malignancies of the ovary account for 10% of all ovarian cancers. Germ cell tumors (GCTs) are diagnosed principally in young subjects whereas sex cord stromal tumors (SCSTs) are more common in adult women. GCTs represent 5% of all ovarian neoplasms and 80% of preadolescent malignant ovarian tumors. Sex cord stromal tumors are rare neoplasms that account for 3–5 % of ovarian malig...

Primary ovarian leiomyoma is a rare tumor, accounting for only 0.5%-1% of benign ovarian neoplasms. About 80 cases have been reported in the literature worldwide to date. Most cases are asymptomatic and usually found incidentally in routine gynecologic workup, during surgery, or at autopsy. Ovarian leiomyoma is diffi cult to be differentiated from other ovarian benign and malignant neoplasms, p...

Cystadenoma, which accounts for 40-50% of all ovarian new growths, is a tumour of adult life, and uncommon in patients under 20 years of age. We have seen two cases, a girl (E.G.) of 13 with a rightsided, thin-walled, unilocular cystadenoma measuring 17 x 13 x 10 cm., and a 12-year-old child (M.O.) with a small, left-sided, multilocular cystadenoma; neither of these two girls had menstruated.

The first tissue-specific angiogenic molecule, endocrine gland-derived vascular endothelial growth factor (EG-VEGF), was identified recently in human ovary, raising hopes of developing tumor type-specific angiogenesis inhibitors. In the present study, we analyzed the expression of EG-VEGF mRNA in normal human tissues and ovarian neoplasms by quantitative real-time reverse transcription-PCR. EG-...