Indomethacin, in combination with prochlorperazine and caffeine (IPC), is often overused by migraine patients who develop medication-overuse headache. Indomethacin clearance is slower in chronic migraine patients overusing IPC combination than in migraine patients only occasionally taking it. The objective of this study was to verify if indomethacin reduced clearance reverted to normal values a...

Nonribosomal peptide antibiotics, including polymyxin, vancomycin, and teixobactin, most of which contain D-amino acids, are highly effective against multidrug-resistant bacteria. However, overusing antibiotics while ignoring the risk of resistance arising has inexorably led to widespread emergence of resistant bacteria. Therefore, elucidation of the emerging mechanisms of resistance to nonribo...

World-wide interlinked computer networks are forming the foundation for computational societies of software agents. Already, these new societies have encountered problems endemic to human communities, such as overusing common resources with thrashing over virtual memory and competition by packets for network time. Unlike with human societies, these inefficiencies can be overcome by reworking th...

Schaeffer (1997, 2000) argues that children lack knowledge of specificity because Dutch children omit determiners and fail to scramble pronouns. Avrutin and Brun (2001), however, find that Russian children place arguments correctly according to whether they are specific or non-specific. This paper investigates object agreement and specificity in early Swahili. Object agreement in Swahili is obl...

A major problem in the decision-making process is poor communication regarding threats and risks between information security experts and decision makers. By their nature, experts have a strong interest in operational details and limited insight into the purpose of the organization as they may not fully understand the mission and business. They are overusing System Language and System Thinking....

Despite the advantages IT has brought to the users, it can also invisibly produce negative impacts at the same time. There have been many cases in recent years showing that mobile technology users receive various kinds of negative feelings due to the ubiquitous nature of this technology. The purpose of this study is to propose a notion termed “ubiquitous technostress” which is the stress caused...

A new question methodology has been developed and used with voting machines in large physics lecture classrooms. The methodology was tested by comparing student performance in voting machine and non-voting machine lecture sections during three consecutive electricity and magnetism quarters of introductory calculus-based physics. Data from The Conceptual Survey of Electricity and Magnetism and c...

People generally fail to produce random sequences by overusing alternating patterns and avoiding repeating ones-the gambler's fallacy bias. We can explain the neural basis of this bias in terms of a biologically motivated neural model that learns from errors in predicting what will happen next. Through mere exposure to random sequences over time, the model naturally develops a representation th...

Can the threat of being shamed or the prospect of being honoured lead to greater cooperation? We test this hypothesis with anonymous six-player public goods experiments, an experimental paradigm used to investigate problems related to overusing common resources. We instructed the players that the two individuals who were least generous after 10 rounds would be exposed to the group. As the natur...

introduction: antibiotics have the potential to adversely affect the microbial community. for anaerobic digestion, a sufficient methanogenic population needs to be preserved in the system. the main aim of this study was determination of inhibitory concentration of oxytetracycline on methanogenic bacteria. methods: a 120 ml jacketed bioreactor with a 90 ml working volume was inoculated granular ...