Sudden cardiac death (SCD) refers to death after an unexpected sudden cardiac arrest in a patient with or without known structural heart disease. The incidence of SCD in the United States ranges from 300 000 to 460 000 events per year, depending on the criteria for SCD used for surveillance. SCD results from a complex interaction between preexisting cardiac substrates, either structural or gene...

The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitocho...

Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral artery occlusion, although mice with diabetes or atherosclerosis may have highe...

Exposure of Escherichia coli to H2O2 leads to two kinetically distinguishable modes of killing: mode I killing occurs maximally near 2 mM H2O2, whereas mode II killing is essentially independent of H2O2 concentrations up to 20 mM. A major portion of H2O2 toxicity is attributed to DNA damage caused by the iron-mediated Fenton reaction. By studying DNA damage during Fenton reactions in vitro, the...

Sunmmiary. Particuilate cell wall polysaccharide synthetase from oat coleoptiles could use either guanosine diphosphate glucose or turidine diphosphate glucose; the latter was a much more effective glucose donor. The neutral polymer derived from uridine diphosphate glu-cose utilization yielded, after cellulase digestion, mostly cellobiose and to a lesser extent a suibstance tentatively identifi...

Purslane(Portulaca oleracea L.) is a local plant in Iran that can easily breed. Chromium is a heavy metal that causes toxicity for the growth and development of plants. To study the effects of  potassium dichromate on growth, efficiency of photosystem II (Fv/Fm), cell membrane stability index (MSI), indexes of oxidative stress and antioxidant properties of purslane, an experiment was d...

The usage of nanoparticles became inevitable in medicine and other fields when it was found that they could be administered to hosts act as oxidants or antioxidants. These oxidative pro-oxidants induce stress-mediated toxicity through the generation free radicals. Some can antioxidants scavenge these radicals help maintaining normal metabolism. oxidant antioxidant properties rely on various fac...