This study was designed to investigate the nutritional significance of the interactions that may occur between oxidized fat and proteins in foods. Herring meal, because of its high content of protein and of highly unsaturated fat, was chosen as the material for study. The first two papers in the series (Lea, Parr & Carpenter, 1958, 1960) dealt mainly with factors influencing the rate of oxidati...

This study was designed to investigate the nutritional significance of the interactions that may occur between oxidized fat and proteins in foods. Herring meal, because of its high content of protein and of highly unsaturated fat, was chosen as the material for study. The first two papers in the series (Lea, Parr & Carpenter, 1958, 1960) dealt mainly with factors influencing the rate of oxidati...

One obvious explanation for the effect of high fat diets in lowering the requirement for thiamine has been that fat metabolism does not require thiamine, while carbohydrate metabolism does. This explanation finds considerable support in one of the known functions of thiamine pyrophosphate. According to current theory, carbohydrate is oxidized to pyruvate, and pyruvate must be decarboxylated for...

1. 2-Methyl[1-(14)C]octanoic acid was synthesized from 2-bromo-octane and (14)CO(2). 2. 2-Methyl[1-(14)C]octanoic acid was readily oxidized to propionic acid and carbon dioxide by mitochondrial preparations from liver, less readily oxidized by adrenal and kidney (mitochondria), and only poorly oxidized by heart, spleen and brown fat (mitochondria). 3. 3beta-Hydroxy[26-(14)C]cholest-5-en-26-oic ...

In contrast to birds, bats are possibly limited in their capacity to use body fat as an energy source for long migrations. Here, we studied the fuel choice of migratory Pipistrellus nathusii (approximate weight: 8 g) by analysing the stable carbon isotope ratio (δ(13)C(V-PDB)) of breath and potential energy sources. Breath δ(13)C(V-PDB) was intermediate between δ(13)C(V-PDB) of insect prey and ...

The physiological function of the mitochondrial uncoupling protein (UCP), UCP3, is still under debate. There is, however, ample evidence to indicate that, in contrast to UCP1, the primary function of UCP3 is not the dissipation of energy. Rather, several lines of evidence suggest that UCP3 is associated with cellular fatty acid metabolism. The highest levels of expression of UCP3 have been foun...

BACKGROUND Low-density lipoprotein (LDL) oxidation is a risk factor for atherosclerosis. Lycopene and tomato-based products have been described as potent inhibitors of LDL oxidation. OBJECTIVES To evaluate the effect of a 2-week supplementation with a carotenoid-rich tomato extract (CRTE) standardized for a 1:1 ratio of lycopene and phytosterols, on post-prandial LDL oxidation after a high-fa...

Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66) were grouped into normal diet (n = 30) and high-fat diet (n = 36) groups and subdivided into controls, hypothyroid...