4-Valine-oxytocin and 1-deamino-4-valine-oxytocin, analogues of the posterior pituitary hormone containing a valine residue in place of the glutamine residue in position 4, have been synthesized by the p-nitrophenyl ester method of peptide synthesis and tested for pharmacological activity. The 4-valine-oxytocin possesses 140 units per mg of oxytocic activity and 240 units per mg of avian vasode...

The frequency of "significant" jaundice of the newborn at this hospital increased from 8-1% of all live births in 1971 to 12-1% in 1972 and 15-4% in 1973. This coincided with an increased use of oxytocic agents and epidural anaesthetics in labour, and a change in the artificial feed given to normal infants. A retrospective study of jaundiced infants born in 1972 failed to explain the increase i...

The labour stencil representing the expected cervimetric progress of normal labour was used in 741 consecutive spontaneous labours to identify high-risk labours which needed oxytocic stimulation. Uterine contractions were stimulated if progress extended two hours past the nomogram, which resulted in shorter labours, fewer instrumental deliveries and caesarean sections, and babies with higher Ap...

OBJECTIVE To compare the efficacy of intravenous ergometrine, intramuscular oxytocin, and oral misoprostol in the control of postpartum hemorrhage. METHODS Mean blood loss, rates of blood loss between 500 and 1000 ml, hematocrit fall greater than 10%, and need for additional oxytocic agents and nature and rates of adverse effects were assessed in this prospective, randomized, controlled study...

The effects of ergometrine 0.5 mg i.v. and of synthetic oxytocin 5 units i.v. on the alpha and the beta adrenoceptive blood vessels of the foreann have been studied by means of volume-pulse plethysmography in 40 gynaecological patients. Ergometrine constricted the alpha and the beta blood vessels. It is thought that the widespread vasoconstriction may precipitate post-partum hypertension or pul...

tioners were frequently in the habit of giving it to hasten tedious labour that was occasioned solely by the presence of some mechanical obstacle. In this way they invoked and called to their aid the powers, as Dr. Barnes has remarked, of a Frankenstein, quite beyond their control, whose unbridled strength might give rise to frightful disasters; in their ignorance they quite forgot that the pro...

Occult or incomplete rupture refers to a surgical scar separating but the visceral peritoneum staying intact. It is usually asymptomatic and does not require emergency surgery. Complete rupture can be: Traumatic: A motor vehicle accident. Incorrect use of oxytocic agent. A poorly conducted attempt at operative vaginal delivery (typically breech extraction with an incompletely dilated cervix). (...

Occult or incomplete rupture refers to a surgical scar separating but the visceral peritoneum staying intact. It is usually asymptomatic and does not require emergency surgery. Complete rupture can be: Traumatic: A motor vehicle accident. Incorrect use of oxytocic agent. A poorly conducted attempt at operative vaginal delivery (typically breech extraction with an incompletely dilated cervix). (...