By searching for molecules that assist MyoD in converting fibroblasts to muscle cells, we have found that p300 and CBP, two related molecules that act as transcriptional adapters, coactivate the myogenic basic-helix-loop-helix (bHLH) proteins. Coactivation by p300 involves novel physical interactions between p300 and the amino-terminal activation domain of MyoD. In particular, disruption of the...

OBJECTIVE The P300 event-related potential shows anterior P300 increases on NoGo tasks (target stimulus=withhold response) relative to Go tasks (target stimulus=commit response). This 'NoGo anteriorization' has been hypothesized to reflect response inhibition. However, silent-count tasks show similar P300 anteriorization. The P300 anteriorization on silent-count tasks relative to Go tasks canno...

UNLABELLED The P300 is a long-latency auditory evoked potential highly dependent on cognitive skills. It is believed that cognitive changes caused or not by depressive symptoms may interfere with the P300. AIM To investigate the influence of aging, cognitive and depression aspects of the P300 latency in elderly people. METHODS Clinical and experimental study with 60 elderly patients with se...

CREB (cAMP responsive element binding protein) protein (CBP) and adenovirus E1A-associated 300 kDa (p300) are histone acetyltransferases, which necessary for multiple cellular processes. Thus, CBP/p300 promising potential antitumor targets. To date, despite various small molecule inhibitors of bromodomain (BRD) having been reported, no specific inhibitor was approved by U.S. Food Drug Administr...

Age has been reported to influence amplitude and latency of the P300 potential. Nevertheless, it is not yet fully understood which brain regions are responsible for these effects. The aim of this study was to investigate age-effects on the P300 potential and the simultaneously acquired BOLD signal of functional MRI. 32 healthy male subjects were investigated using an auditory oddball paradigm. ...

The form of the average cortical potential is determined both by the physical characteristics of the eliciting stimulus and by the nature of the information processing activities invoked by that stimulus. In particular, much evidence has shown that P300, a component with a positive polarity, and a modal latency of about 300 msec, is considerably enhanced in the average evoked potential (ALP) wh...

The regulation of firing thresholds of cortical neurons was suggested as one of the mechanisms underlying the generation of the P300 component in the human event-related potential. According to this hypothesis, the detection of an important stimulus produced the widespread inhibition of "irrelevant" networks, interrupting their ongoing activity and facilitating the analysis of selected informat...

The effects of stimulus quality on the amplitude, peak latency, onset latency, and duration of the P300 component of the event-related brain potential were studied in patients with either a left or a right anterior temporal lobectomy and in normal controls. Stimulus quality was reduced by adding "noise" letters to words which signalled either a left or a right hand button press. Consistent with...

P300 event related potential was recorded in 115 healthy controls with a mean age of35.9±14.81 years and a male : female ratio of 72 : 43. There was significant difference in the P300 latency in < 40 years as compared to ≥ 40 years group (p< 0.001). There was no significant difference between males and females. There was a strong positive correlation between age and P300 latency (p< 0.001). The...

The present meta-analysis investigated the clinical utility of the auditory P300 latency event-related potential in differentiating patients with Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and unaffected controls. Effect size estimates were computed from mean P300 latency measurements at midline electrodes between patients and unaffected controls using the random e...