Paget-Schroetter syndrome, also known as effort thrombosis, is a relatively rare disease process characterized by primary thrombosis to the subclavian and axillary veins. It usually presents in younger individuals, commonly affecting the dominant side upper extremity, and the diagnosis relies on a combination of imaging, laboratory tests, and clinical presentation. Upper extremity deep vein thr...

Paget-Schroetter syndrome (PSS) is thrombosis of the deep veins draining the upper extremity due to anatomic abnormalities of the thoracic outlet that cause subclavian compression and subsequent thrombosis, leading to thrombus formation in the subclavian vein. Vigorous arm activity in sports is a known risk factor. Here, we report a case of Paget-Schroetter syndrome in a 31-year-old male non-pr...

Differential diagnoses of pigmented lesions of the nipple include melanocytic nevus, melanosis of the nipple, seborrheic keratosis, pigmented basal cell carcinoma, melanoma and Paget disease. The histologic exam with appropriate immunohistochemistry is a fundamental tool to achieve a correct diagnosis. We present a patient with a pigmented lesion of her right nipple revealing mammary Paget dise...

Introducción: La enfermedad de Paget es un trastorno metabólico etiología desconocida, secundario a incremento en la función los osteoclastos y consecuente respuesta osteoblastos formación exagerada hueso. Compromete con mayor frecuencia el fémur proximal y, menudo, se diagnostica incidentalmente. Se presenta caso una mujer antecedente pseudoartrosis cadera izquierda, indicaciones prótesis tota...

BrMedJf 1989;299:1579-81 It is now nearly 120 years since Wilks' described the condition that Sir James Paget called "osteitis deformans."2 Although Paget considered that he was describing a new disease, the fact that he was able to collect data on 23 cases during his lifetime suggests that it was an established condition. On 13 December 1882 in the Bradshaw lecture "On some rare and new diseas...

Extramammary Paget disease (EMPD) is a rare cutaneous malignancy. The most common presentation of EMPD is the vulva followed by perianal involvement. Most cases are localized to the dermis with treatment focused on surgery, topical treatment or radiotherapy. Recurrence is frequent despite therapies utilized. Metastatic extramammary Paget disease is uncommon and, as such, standard treatment guid...

Extramammary Paget disease is a rare disease. Different treatment options are used for its management, among them treatment with imiquimod. Our aim is to clarify the efficacy and safety of the use of topical imiquimod cream in the treatment of extramammary Paget disease. In this article the current literature in Pubmed and Scopus on this topic is reviewed. According to the literature the topica...

BACKGROUND Radiographic sacroiliitis is the hallmark of ankylosing spondylitis (AS), and detection of acute sacroiliitis is pivotal for early diagnosis of AS. Although radiographic sacroiliitis is a distinguishing feature of AS, sacroiliitis can be seen in a variety of other disease entities. CASE PRESENTATION We present an interesting case of sacroiliitis in a patient with Paget disease; the...

OBJECTIVES To determine the prevalence and spectrum of retinal changes in juvenile Paget disease. METHODS Observational case series and literature review with analysis. Patients with clinical and molecular evidence of juvenile Paget disease were recruited by members of the International Hyperphosphatasia Collaborative Group. Participants underwent ophthalmic examinations consisting of at leas...

Introducción: el ácido zoledrónico es un inhibidor de la resorción ósea que se utilizaen tratamiento enfermedad Paget, prevención osteoporosis inducidapor glucocorticoides y en mujeres posmenopáusicas hombres.