SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. Genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may arise due to non-complete manifestations of SAPHO: either acne and arthriti...

Palmoplantar (palmo meaning palm of the hand, plantar sole foot) pustulosis (PPP) is a persistent (chronic) condition that causes blisters filled with fluid on palms and soles feet. The skin can be very itchy painful, particularly if there are deep cracks in skin. persistent, but symptoms vary, becoming better worse over time, often no obvious cause.

Palmoplantar keratodermas (PPKs) represent a diverse group of hereditary and acquired disorders characterized by hyperkeratosis of the skin on the palms and soles [1]. The three major patterns of involvement are diffuse, focal and punctate. There are clinical distinguishing features for each disease in this group, for example, transmigration to areas beyond the palmoplantar skin. Also the exten...