We describe a case of an adult born in the United States who had subacute sclerosing panencephalitis (SSPE). We discuss the possibility that the patient contracted subclinical measles during the 1989-1991 measles epidemic in the United States.

Lymphocyte subsets in cerebrospinal fluid (CSF) and peripheral blood were studied using monoclonal antibodies, in patients with subacute sclerosing panencephalitis, eight of whom were at stage 2 and seven at stage 4. Eighteen subjects affected with non immunological diseases constituted the controls. Regardless of the stage, patients with subacute sclerosing panencephalitis had lower percentage...

The pathogenesis of the slow virus encephalopathies and multiple sclerosis is reviewed within the framework of the immune response. The diseases are analyzed for the component of the immune response that appears to be crucial to the host's failure to control the disease. Thus, the absence of an immune response in the spongiform encephalopathies appears to reflect a failure of antigen recognitio...

Subacute sclerosing panencephalitis is a slowly progressive neurodegenerative disorder occurring in childhood and adolescence and is characterised by dementia, ataxia, myoclonias and other neurological focal signs, with an invariably fatal outcome. The author reviews the subject, focussing on epidemiology, clinical features, measles virus behaviour, host immune reactions, measles prophylaxis an...

Introduction Subacute sclerosing panencephalitis (SSPE) is a rare disease which predominantly affects children of school age. The clinical features include an insidious afebrile onset with behavioural disturbance and progressive dementia sometimes associated with epilepsy. Later akinetic mutism and myoclonic jerks with pyramidal and extrapyramidal signs appear. Finally there is progressive deco...

enough for accurate localization of the pus, and a lumbar puncture would have added only hazard to the diagnosis. When abscesses are metastatic or multiple the problems of localization are difficult. In solving these problems-which include abscesses in the deep frontal and the parietal regions -ventriculography, electroencephalography, and brain scanning play an important part. Hence it is a ma...

Agarose electrophoresis of cerebrospinal fluid from two patients with subacute sclerosing panencephalitis revealed in both cases several homogeneous bands in the intermediate and basic gammaglobulin region. The bands were identified as IgG with various degrees of kappa or lambda light-chain restriction in crossed immunoelectrophoresis. Homogeneous IgG bands were separated by preparative agarose...