Amaç: Bu çalışmada, akut şizofreni hastalarında ajitasyonun tedavisinde uzamış salınımlı ketiyapin fumarat’ın (XR) etkinliğini değerlendirmek amaçlandı. Yöntem: Üç haftalık açık etiketli olarak tasarlanan bu çalışmaya yatan veya ayaktan şizofreni hastaları dahil edildi. Ketiyapin XR 1. gün 300 mg, 2. gün 600 mg ve 3. günden itibaren araştırmacının takdirine göre 400-800 mg/gün dozunda uygulandı...

In this study, we investigated the relationships between observed social withdrawal (Positive and Negative Syndrome Scale [PANSS] Passive Social Withdrawal and PANSS Active Social Avoidance), subjectively experienced social withdrawal (Social Functioning Scale [SFS] Withdrawal and SFS Interpersonal Behavior), and their associations to the underlying psychological patterns of Object Relations an...

BACKGROUND Loss of gray matter has been previously found in early-onset schizophrenic patients. However, there are no consistent findings between studies due to different methods used to measure grey matter volume/density and influences of confounding factors. METHODS The volume of gray matter (GM) was measured in 29 first episode early-onset schizophrenia (EOS) and 34 well-matched healthy co...

Positive psychotic symptoms, such as threat/"control-override" delusions or command hallucinations, have been related to aggression in patients with schizophrenia. However, retrospective data collection has hampered evaluation of the direct influence of psychopathology on aggressive behavior. In this study, we monitored aggressive behavior and psychopathology prospectively and in close temporal...

BACKGROUND We present a systematic review and meta-analysis of the available clinical trials concerning the usefulness of aripiprazole in the treatment of the psychotic symptoms in bipolar disorder. METHODS A systematic MEDLINE and repository search concerning clinical trials for aripiprazole in bipolar disorder was conducted. RESULTS The meta-analysis of four randomised controlled trials (...

Obermeier and colleagues address an at-first glance trivial issue, which, however, has major implications on the analysis and interpretation of clinical trials: The scaling of the Positive and Negative Syndrome Scale (PANSS). The original version of the scale uses a 1–7 rating system that creates major problems of interpretation when it comes to the calculation of responder rates based on perce...

The design of the Positive and Negative Syndrome Scale (PANSS) with item levels ranging from 1 to 7 leads to the trivial result that the 30-item scale's zero level (no symptoms) is 30. This causes serious problems when ratios are calculated which always implicitly depend on a natural zero point (equals 0). Recent publications concerning efficacy of antipsychotics correctly suggest a subtraction...

Results The pooled effect size for acute manic symptoms was equal to 0.34. The NNT was 6 for aripiprazole vs placebo concerning response at week 3 and equal to 14 concerning remission. The average day response started was day 3. The suicide rates were negligible for all groups. In contrast to the individual isolated trials, the meta-analysis for acute bipolar depression suggests a significant d...

The Positive and Negative Syndrome Scale (PANSS) was originally designed as a rating system that provides balanced representation of positive and negative symptom features. Evidence from recent factor-analytic studies suggests that a five-dimensional solution appears to best fit the psychopathological data as assessed with the PANSS. To investigate the dimensional structure, we administered the...

BACKGROUND There is concern over the methods used to evaluate antipsychotic drugs. AIMS To assess the clinical relevance of findings in the literature. METHOD A systematic review identified studies of antipsychotics that used the Brief Psychiatric Rating Scale (BPRS) and Positive and Negative Syndrome Scale (PANSS). A published method of translating these into Clinical Global Impression - C...