Noscapine is a potential anticancer drug isolated from the opium poppy Papaver somniferum, and genes encoding enzymes responsible for the synthesis of noscapine have been recently discovered to be clustered on the genome of P. somniferum. Here, we reconstitute the noscapine gene cluster in Saccharomyces cerevisiae to achieve the microbial production of noscapine and related pathway intermediate...

DRUG ADDIcTIoN, especially through the use of poppy (Papaver somniferum Linn.) and hemp (Cannabis sativa Linn.), is the main concern of this paper. Although the use of these two plants in medieval Islam was extensive, yet little has been written on this timely subject by historians of medicine and pharmacology. Consulting contemporary original sources, it is my hope to sketch a history of their...

The alkaloid content in industrial opium poppies (Papaver somniferum L.) has been studied by numerous authors, but not in ornamental cultivars.The aim of the study was to investigate the content of morphine, codeine, and papaverine in P. somniferum cultivars by high performance liquid chromatography (HPLC) and capillary electrophoresis (CE). The studied poppy capsules were either grown from the...

Opiates and related molecules are medically essential, but their production via field cultivation of opium poppy Papaver somniferum leads to supply inefficiencies and insecurity. As an alternative production strategy, we developed baker's yeast Saccharomyces cerevisiae as a microbial host for the transformation of opiates. Yeast strains engineered to express heterologous genes from P. somniferu...

Tyrosine decarboxylase (TyDC), a type II pyridoxal 5'-phosphate decarboxylase, catalyzes the decarboxylation of tyrosine. Due to a generally high sequence identity to other aromatic amino acid decarboxylases (AAADs), primary sequence information is not enough to understand substrate specificities with structural information. In this study, we selected a typical TyDC from Papaver somniferum as a...

BACKGROUND Anaphylaxis during anaesthesia is fatal in 3-9% of patients and analgesics, including opioids, and is the second most common medicament-related cause, although the prevalence is underestimated. We recently found that patients may generate IgE antibodies to opium seeds. OBJECTIVES To determine the diagnostic accuracy of specific antibodies to morphine, codeine, rocuronium and oil bo...

En el presente artículo analizo la producción legal de adormidera (Papaver somniferum L.) en España. primer lugar, reviso legislación histórica sobre materia, caracterizada por ortodoxia respecto al régimen internacional y consiguiente imbricación entre las decisiones a ese nivel nacional. Posteriormente, describo cultivo del estupefaciente, un producto estratégico tradición estanco, caracteriz...

Contents 1. Introduction 2. Principal plants that have contributed to the development of modern analgesic and anti-inflammatory drugs 2.1. Papaver somniferum 2.2. Salix species 2.3. Cannabis sativa 2.4. Capsicum sp. 2.5. Panax ginseng 2.6. Tanacetum parthenium 2.7. Aconitum sp. 3. New plant-derived substances with potential antinociceptive or anti-inflammatory properties 3.1 Siphocampylus verti...