A 17-year-old male presented with a 4-year history of asymptomatic, fleshy, spiny papules around the coronal rim of the glans penis (Figure). The patient was uncircumcised and there was no history of venereal exposure. Physical examination revealed several rows of 2-3 mm pearly fleshy, warty, papules located circumferentially over the corona of the glans penis. Pearly penile papules are small, ...

A 51 year old woman was referred to dermatology clinic with multiple asymptomatic erythematus papules and plaques on her back, which she had developed over the previous 2 months ago. In the dermatological examination, there were multiple atrophic papules with hypopigmented centers and sharp borders on her back, some of which were annular with elevated violaceous borders (Figures 1, 2). Fu...

Fibrous papules of the face are hamartomas characterized by stellate-shaped stromal cells, multinucleated giant cells, and proliferative blood vessels in the dermis. The pathogenesis of fibrous papules remains unclear. There is a striking microscopic resemblance between fibrous papules and tuberous sclerosis complex (TSC)-associated angiofibromas. A germline mutation of the TSC1 or TSC2 gene, l...

A punch biopsy of the axillary region was performed for histopathological study, staining with hematoxylin-eosin (Figure 2), periodic acid-Schiff (PAS), and Congo red. The histological findings included papillomatosis, orthokeratotic hyperkeratosis and epidermal acanthosis, focal atrophy of the granular layer, and mild hyperpigmentation of the basal layer of the epidermis. There was a moderate ...

Pearly penile papules (PPP) (also often referred to as pink pearly papules or pink penile papules) have been noted by many anatomists and dermatologists over the past 250 years, including such distinguished names as Littre and Morgagni. They commonly present to clinics for sexually transmitted diseases as one of the minor "rarities" and the source of much anxiety for worried adolescents. No agr...