OBJECTIVES To compare different screening procedures for hydroxychloroquine sulfate (Plaquenil) toxicity at different stages of damage. METHODS Ten patients were studied using 10-2 automated fields, multifocal electroretinography, spectral domain optical coherence tomography (SD-OCT), and fundus autofluorescence. RESULTS All 10 patients used hydroxychloroquine for more than 6 years, and tho...

OBJECTIVE To describe the changes observed with optical coherence tomography in group 2A idiopathic juxtafoveolar retinal telangiectasis. METHODS We retrospectively reviewed the medical records of 13 patients (25 eyes). All eyes underwent optical coherence tomography examination consisting of 6 radial scans, fundus color photography, and fluorescein angiography. We calculated retinal foveal a...

Two experiments are reported that examine the influence of semantic contextual constraints on an individual's ability to use parafoveal visual information. Subjects were presented either a word (reptile) or a row of Xs in foveal vision along with a parafoveal nonword (snckks) centered 2.3 degrees or 5 degrees to the left or right of fixation. The subjects were asked to pronounce the parafoveal ...

The boundary paradigm, in combination with parafoveal masks, is the main technique for studying parafoveal preprocessing during reading. The rationale is that the masks (e.g., strings of X's) prevent parafoveal preprocessing, but do not interfere with foveal processing. A recent study, however, raised doubts about the neutrality of parafoveal masks. In the present study, we explored this issue ...

PURPOSE To report expanded SD-OCT findings of HCQ retinopathy that may assist the clinician in earlier diagnosis. To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. METHODS Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopa...

Parafoveal preprocessing of upcoming words and the resultant preview benefit are key aspects of fluent reading. Evidence regarding the development of parafoveal preprocessing during reading acquisition, however, is scarce. The present developmental (cross-sectional) eye tracking study estimated the magnitude of parafoveal preprocessing of beginning readers with a novel variant of the classical ...

PURPOSE To evaluate optic nerve characteristics independent of systemic factors predisposing to parafoveal scotoma in normal tension glaucoma. METHODS We included 40 patients with bilateral normal tension glaucoma with parafoveal scotoma (visual field defect in one hemifield within 10° of fixation with at least one point at p<1% lying at the two innermost paracentral points) in only one eye (...