نتایج جستجو برای: pathogenesis clinical implications
تعداد نتایج: 1570872 فیلتر نتایج به سال:
Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications
Aortic stenosis (AS) is a common valvular heart disease in the Western populations, with an estimated overall prevalence of 3% in adults over 75 years. To understand its patho-biological processes represents a priority. In elderly patients, AS usually involves trileaflet valves and is referred to as degenerative calcific processes. Scientific evidence suggests the involvement of an active "athe...
Normally, the gastrointestinal epithelium provides a semi-permeable barrier which allows nutrients to be absorbed while preventing larger, potentially toxic, antigenic, or pathogenic molecules or organisms from crossing into the bloodstream. Pathogenicallyincreased intestinal permeability predisposes the individual to diffusion of antigenic food molecules and translocation of bacteria and/or ye...
The article by SZEFLER and LEUNG [1] on corticosteroid-resistant asthma is a useful and thorough review of a difficult topic. I am, however, concerned that three different conditions are becoming confused and this could have important implications for therapy. These conditions are: 1) difficult to control asthma; 2) corticosteroidresistant asthma; 3) other respiratory disease incorrectly diagno...
Carbamylation describes a nonenzymatic posttranslational protein modification mediated by cyanate, a dissociation product of urea. When kidney function declines and urea accumulates, the burden of carbamylation naturally increases. Free amino acids may protect proteins from carbamylation, and protein carbamylation has been shown to increase in uremic patients with amino acid deficiencies. Carba...
Many structural, behavioral, and pharmacological interventions imply that favorable treatment effects in musculoskeletal pain states are mediated through the correction of muscle function. The common theme of these interventions is captured in the popular idea that structural or psychological factors cause muscle hyperactivity, muscle overwork, muscle fatigue, and ultimately pain. Although symp...
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