objective: assessments of cell reactions such as motility, orientation and activation to the topography of the substratum will assist with the fabrication of a proper implantable scaffold for future tissue engineering applications.the current challenge is to analyze the orientation effect of elecrospun nanofibers of poly (ε-caprolactone) (pcl) on viability and proliferation of mouse embryonic s...

Peripheral nerve injury is a serious clinical problem to be solved. There has been no breakthrough so far and neural tissue engineering offers a promising approach to promote the regeneration of peripheral neural injuries. In this study, emulsion electrospinning technique was introduced as a flexible and promising technique for the fabrication of random (R) and aligned (A) Poly(ε-caprolactone) ...

Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...

Objectives: Postsurgical adhesion is one of the common complications after surgery. Some anti-adhesion barriers are commercially available which are not customary used by physicians as much as expected because of ineffectiveness. Recently, nanofibers have been introduced as anti-adhesion barriers with t...

nanofibrous scaffolds produced by electrospinning have attracted much attention, recently. aligned and random nanofibrous scaffolds of poly (vinyl alcohol) (pva), poly (ε-caprolactone) (pcl) and nanohydroxyapatite  (nha) were fabricated by electrospinning method in this study. the composite nanofibrous scaffolds were subjected to detailed analysis. morphological investigations revealed that the...

Axonal re-myelination in injured central nervous system (CNS) has been a scientific challenge. Focal delivery of Oligodendrocyte Progenitor Cells (OPCs) provides promising approach. We used a novel bioengineering technique to create co-electrospun nanofibers of Gelatin and Poly-ɛ-caprolactone (PCL) to be used as a scaffold for neural tissue regeneration. Growth and differentiation of Oligodendr...

The last decade has seen artificial blood vessels composed of natural polymer nanofibers grafted into human bodies to facilitate the recovery of damaged blood vessels. However, electrospun nanofibers (ENs) of biocompatible materials such as chitosan (CTS) suffer from poor mechanical properties. This study describes the design and fabrication of artificial blood vessels composed of a blend of CT...

Objective(s): Biological effects of MSCs on aligned and random nanofibrous scaffolds of PCL/PVA/nHA were investigated in this study. Materials and Methods: Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were eval...

Incisional hernia is the most common postoperative complication, affecting up to 20% of patients after abdominal surgery. Insertion of a synthetic surgical mesh has become the standard of care in ventral hernia repair. However, the implementation of a mesh does not reduce the risk of recurrence and the onset of hernia recurrence is only delayed by 2-3 years. Nowadays, more than 100 surgical mes...