pe_pgrs

Aniek D. van der Woude Debasmita Sarkar Apoorva Bhatt Marion Sparrius Susanne A. Raadsen Louis Boon Jeroen Geurtsen Astrid M. van der Sar Joen Luirink Edith N.G. Houben Gurdyal S. Besra Wilbert Bitter

Background: Various cell surface proteins of pathogenic mycobacteria have been implicated in virulence. Results: A screen for secretion defects of specific cell surface proteins in Mycobacterium marinum identified predominantly lipooligosaccharide (LOS) biosynthesis mutants. Conclusion: Defects in LOS biosynthesis alter the release of cell surface proteins. Significance: Ten novel genes are des...

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Variable Expression Patterns of Mycobacterium tuberculosis PE_PGRS Genes: Evidence that PE_PGRS16 and PE_PGRS26 Are Inversely Regulated In Vivo

Journal: :Journal of Bacteriology 2006

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Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis.

Journal: :Journal of medical microbiology 2008

M G Chaitra M S Shaila R Nayak

The PE and PPE proteins of Mycobacterium tuberculosis form a source of antigenic variation among different strains of this bacterium. Two of the PE_PGRS protein-encoding genes, rv3812 and rv3018c, are expressed in pathogenic mycobacteria and are implicated, respectively, in the persistence of the organism in macrophages and in virulence. Peptides derived from these proteins have been predicted ...

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