Studies with 26 clones of L. donovani promastigotes derived from three different Indian isolates indicated that wild type parasites are mixture of stibanate sensitive and resistant cells. Both forms of the parasite were resistant to the drug. Infection with resistant parasites appears to be the primary reason of high rate of pentavalent antimony unresponsiveness among Indian kala-azar patients....

Although, in southern Europe, there has been considerable experience in the treatment of visceral leishmaniasis (VL) in HIV-positive patients, the optimal therapy has yet to be established. Pentavalent antimony salts, free amphotericin B deoxycholate (ABD) and lipidic formulations of amphotericin B are the drugs most commonly used. Treatment with pentavalent antimonials requires daily injection...

The introduction of pentavalent vaccine containing Haemophilus influenzae type b antigen in Indonesia's National Immunization Program occurred nearly three decades after the vaccine was first available in the United States and 16 years after Indonesia added hepatitis B vaccine into the program. In this study, we analyzed the process that led to the decision to introduce pentavalent vaccine in I...

Pentavalent combination vaccines are important tools to strengthen the immunization programs in numerous countries throughout the world. A large number of countries have recognized the value of combination vaccines and have introduced whole cell pentavalent vaccines into their immunization programs. A phase III, multi-center, randomized, single blinded study of a fully liquid pentavalent DTwP-H...

In this study, we construct the hydroxide water cluster, OH-(H2O)6, that (a) could support a stable hydroxide ion with a four-coordinated (pentavalent) hydroxide oxygen and (b) displays hydroxide ion migration. We study the energetic stability and dynamical evolution of the system at different internal temperatures and analyze the corresponding "dynamically averaged" vibrational density of stat...

A graph is said to be symmetric if its automorphism group acts transitively on its arcs. In this paper, a complete classification of connected pentavalent symmetric graphs of order 12p is given for each prime p. As a result, a connected pentavalent symmetric graph of order 12p exists if and only if p = 2, 3, 5 or 11, and up to isomorphism, there are only nine such graphs: one for each p = 2, 3 ...

A few months ago we refused to publish in this journal an advertisement of an antimony preparation which was said to be a specific remedy for malaria in all forms. This preparation appeared to be an ordinary pentavalent one. In our present number we publish an article by P. C. Sen Gupta on malaria complicating kala-azar, in which it is recorded that malaria may occur during or immediately after...

The certification of Standard Reference Material (SRM is a registered trademark of NIST) 3103a As Spectrometric Solution is based on the gravimetric preparation value that is verified by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. A disagreement between the gravimetric and the spectrometric values for a batch of As calibration solutions led to the discovery ...

This work reports the isolation and spectroscopic characterization of pentavalent metal–imido species that are reactive towards N-group transfer reactions including alkene aziridination C–H amination.