Pentoxifylline, a methylxanthine, is an effective modulator of alkylating agents in tissue culture and in human tumor explants in mice. In this Phase I trial, escalating dose controlled release pentoxifylline was administered p.o. 3 times daily for 5 days (15 doses) with a constant dose of thiotepa, 40 mg/m2 i.v. on day 2. Forty-four courses of escalating doses of pentoxifylline varying from 40...

We investigated effects of pentoxifylline during septic shock. Two-year-old (10-12 kg), purpose-bred beagles were infected i.p. with Escherichia coli 0111:B4 (1.2-1.5 x 10(9) colony-forming units per kilogram b.wt.) in a fibrin clot and then immediately treated with one of five doses of pentoxifylline (0.5-20 mg. kg-1. h-1 i.v.) as a 36-h continuous infusion or placebo. All animals received ant...

Previous studies have reported that pentoxifylline, a phosphodiesterase inhibitor, attenuates experimental mesangial proliferative glomerulonephritis. This study hypothesized that pentoxifylline could also attenuate the renal disease progression in rats with remnant kidney. After 5/6 subtotal nephrectomy, rats developed progressively elevated proteinuria and plasma creatinine, glomerulosclerosi...

Pentoxifylline, a methylxanthine, is an effective modulator of alkylating agents in tissue culture and in human tumor expiants in mice. In this Phase I trial, escalating dose controlled release pentoxifylline was ad ministered p.o. 3 times daily for 5 days (15 doses) with a constant dose of thiotepa, 40 mg/m2 i.v. on day 2. Forty-four courses of escalating doses of pentoxifylline varying from 4...

Pentoxifylline, 0.30 mg/kg/min, significantly reduced cerebral blood flow by 10-44% in 19 of 23 regions studied in conscious spontaneously hypertensive rats. Bilateral ligation of the common carotid arteries reduced cerebral blood flow to 24-46% of resting values in 20 structures; a further reduction to 10-27% of resting values was seen after pentoxifylline in 10 cortical or subcortical structu...

BACKGROUND It is well known that the hippocampus, the CA1 Pyramidal cells in particular, is selectively vulnerable during global cerebral ischemia. Recently, it is observed that pentoxifylline has a neuroprotective effect. This study explored the pharmacological relationship between ischemiainduced cell death of the hippocampus and the efficacy of a vasodilator agent (pentoxifylline) in the pre...

A two-molecule chitinolytic enzyme system (endoand exo-chitinase) hydrolyzes and degrades the chitin polymers. Therefore, it is imperative to discover novel compounds for inhibiting chitinolytic enzymes to prevent insect growth. This research examined the effect of pentoxifylline (a dimethylxanthine chitinase inhibitor) on inhibition of endoand exo-chitinolytic enzyme activities in eastern subt...

Advances in radiology have helped in early diagnosis, surveillance and proper management of disease processes. SPECT scintigraphy is an imaging modality that helps in the detection & diagnosis of facial & skull osteomyelitis and is also useful for detecting silent lesions. Pentoxifylline-tocopherol together helps in faster healing of diseased bone. Pentoxifylline reduces blood viscosity and thu...

BACKGROUND Pentoxifylline has anti-inflammatory properties and could suppress some inflammatory processes including tumor necrosis factor-alpha (TNF-α) production. We assessed the effects of a two-month administration of pentoxifylline on nuclear factor-kappa B (NFκB) pathways in patients with coronary artery disease (CAD) in which inflammatory pathways, especially NFκB transcription factors, h...

Sullivan et al. Inhibition of the Inflammatory Action of Interleukin-1 and Tumor Necrosis Factor (Alpha) on Neu trophil Function by Pentoxifylline, Infection and Immunity, vol.56:1722-1729 (1988). Strieter et al. Cellular and Molecular Regulation of Tumor Necrosis Factor Alpha Production by Pentoxifylline. Bio chemical and Biophysical Research Communication vol. 155:1230-1236 (1988). Schade. Ul...