The acute administration of 1RaS,cis cypermethrin, deltamethrin, fenvalerate and permethrin produced a dose-dependent lowering of the concentration of pentylenetetrazol required to elicit a seizure in rats. The proconvulsant action of cypermethrin displayed stereospecificity in that the 1RaS,cis isomer was the most potent compound tested, while the non-insecticidal isomer, 1SaR,cis cypermethrin...

To clarify the question whether the duration of hypoxia exposure has an influence on the point in time or the strength of hypoxic preconditioning, hypoxia exposure of rats lasting 1 and 8 h was tested regarding the modification of susceptibility to acute pentylenetetrazol-induced seizures. Following the short-lasting (1 h) hypoxia, the maximum level of preconditioning action was observed 7 days...

objective: antiepileptic drugs (aeds) that are usually used for treatment of epilepsy have substantial side effects and about 30% of patients continue to have seizures with current aeds therapy. some herbs which traditionally used in the management of seizures of many rural areas of the developing countries have shown anticonvulsant activity in modern pharmacological bioassays. the aim of the p...

objective(s): epilepsy is a neurodevelopmental disorder which is strongly influenced by genetic and environmental factors. gestational stress has been shown to be an important factor for affecting seizure susceptibility. the present study was conducted to address whether gestational stress may affect pentylentetrazol (ptz)-induced epileptic behavior in rat offspring in a sex- and age- dependent...

introduction: regarding chronic nature of epilepsy and its side effects and to access the effective treatment procedures, herbal medicine has received remarkable interest. the aim of this study was to determine the anticonvulsant effects of hydro-alcoholic extract of anethum graveolens seed on pentylenetetrazol (ptz) -induced seizure in male mice. methods: fifty-six albino male mice were divide...

introduction: epilepsy is a neural disorder in which abnormal plastic changes during short and long term periods lead to increased excitability of brain tissue. kindling is an animal model of epileptogenesis which results in changes of synaptic plasticity due to repetitive electrical or chemical sub-convulsive stimulations of the brain. lateral hypothalamus, as the main niche of orexin neurons ...