The goal of this study was to elucidate the neurotoxic effects of repeated exposure to gasoline, perchloroethylene or toluene on male rats, in addition to evaluate the interventive role of certain nutraceuticals against the neurodegenerative insult produced by inhalants abuse. The experimental groups were assigned as follows: Gp(1) control; Gp (2) exposed to gasoline vapors (3200 ppm) for quart...

Perchloroethylene (PERC) is the most commonly used drycleaning solvent. PERC can enter the body through respiratory and dermal exposure. Symptoms associated with exposure include: depression of the central nervous system; damage to the liver and kidneys; impaired memory; confusion; dizziness; headache; drowsiness; and eye, nose, and throat irritation. Repeated dermal exposure may result in derm...

Metabolism of perchloroethylene (Perc) occurs by cytochrome P450-dependent oxidation and glutathione (GSH) conjugation. The cytochrome P450 pathway generates tri- and dichloroacetate as metabolites of Perc, and these are associated with hepatic toxicity and carcinogenicity. The GSH conjugation pathway is associated with generation of reactive metabolites selectively in the kidneys and with Perc...