PURPOSE Infectious, wound and soft tissue events contribute to the morbidity of radical cystectomy but the association between these events and antibiotic prophylaxis is not clear. We sought to describe the contemporary use of antibiotic prophylaxis in radical cystectomy and adherence to published guidelines, and identify regimens with the lowest rates of infectious events. MATERIALS AND METH...

OBJECTIVE To evaluate incidence and risk factors of postoperative meningitis, with special emphasis on antibiotic prophylaxis, in a series of 6243 consecutive craniotomies. METHODS Meningitis was individualized from a prospective surveillance database of surgical site infections after craniotomy. Ventriculitis related to external ventricular drainage or cerebrospinal fluid shunt were excluded...

OBJECTIVE We aimed to compare the efficacy of short-term (<24 hours) versus longer-term antibiotic prophylaxis (≥24 hours) in open heart surgery. BACKGROUND The optimal duration of antibiotic prophylaxis for adults undergoing cardiac surgery is unknown and guideline recommendations are inconsistent. METHODS We searched MEDLINE, EMBASE, CINAHL, and CENTRAL for parallel-group randomized trial...

This study looked at the Perioperative Antibiotic Prophylaxis (PAP) practice among 22 colorectal surgeons in Bahrain by way of a hand delivered questionnaire. Fourteen surgeons completed responses. For PAP, all fourteen used intravenous (IV) antibiotics in combination with mechanical bowel cleansing. Four (28.5%) used combined oral and IV PAP. One used IV antibiotics only. None used oral PAP al...

Aims and objectives: Intraoperative antibiotics may be effective in elective surgery; there may be an advantage to starting antibiotics preoperatively when there is already an infective focus, such as compound facial fractures. The purpose of this study is to compare preoperative and intraoperative antibiotic prophylaxis in compound facial fractures. Materials and methods: This is a prospective...

A study of twenty-five cases of prosthetic valve endocarditis suggests that the antibiotics used for perioperative prophylaxis may alter the type and antibiotic sensitivity of organisms which subsequently infect the artificial valves. Based on the results of this study, the authors have been able to modify their prophylactic regime to encompass these organisms and to predict the antibiotics mos...

BACKGROUND Procedures for perioperative infection prophylaxis in elective colon cancer surgery consist of preoperative mechanical preparation, chemical preparation with oral antibiotic administration, perioperative intravenous antibiotic administration, and others. However, the optimal combination of these procedures and drugs and their durations of administration have not yet been established....

BACKGROUND The additional value of perioperative antibiotic prophylaxis in preventing infectious complications after emergency cholecystectomy for acute cholecystitis is a much-debated subject in the surgical community. Evidence-based guidelines are lacking, and consequently the use of antibiotic prophylaxis varies greatly among surgeons and hospitals. Recently, high-level evidence became avail...

BACKGROUND The goal of antibiotic prophylaxis is not to sterilize the operative field, but to minimize the perioperative bacterial load to the level that will not result in clinical infection. Patient-related risk factors, such as poor nutritional status, smoking, diabetes and impaired immune system, and nature of the surgery should be reviewed when considering prophylactic use of antibiotics. ...