paclitaxel is a highly effective anticancer agent. it is active against a broad range of cancers that are generally considered refractory to conventional chemotherapy. paclitaxel induces a peripheral neuropathy (pn) that is characterized by sensory symptoms such as numbness and paresthesia in a glove and stocking distribution. pn may be severe and dose limiting at initial doses above 275 mg/m2....

many experimental studies have reported behavioral improvement after transplantation of peripheral nerve tissue into the contused spinal cord, even in large animals. the safety of this treatment in human remains unknown. in this translational phase 1 study, safety of peripheral nerve grafting for chronic spinal cord injuries and possible outcomes are being reported. twelve complete motor spinal...

mitochondria play key roles in many cell functions including energy production, fatty acid metabolism, pyrimidine biosynthesis, calcium homeostasis, and aging. they also regulate crucial signaling cascades such as apoptosis and oxidative stress. the proteome is often used to investigate the functional correlations on protein levels. based upon the human, genome there is estimated 2000 to 2500 a...

background : an elevation in the mean percentages of the gamma delta t lymphocytes per total t cells in the epithelium of the small intestine has a diagnostic value for celiac disease.  this study aimed to measure the percentages of the peripheral blood gamma delta t lymphocytes in the adults' celiac disease and healthy controls. materials and methods: in this case-control study the absolute nu...

background: multiple sclerosis (ms) is known to affect essentially the central nervous system; however, peripheral nerve involvement, as an additional cause of disability, has been recently noticed. objectives: this study was aimed to perform detailed electrodiagnostic assessments in ms patients to evaluate peripheral nervous system involvement. materials and methods: a total of eighty ms patie...

objective(s):biochemical markers are important for the timely diagnosis and follow-up of ischemic events. most of the markers have been previously studied in the context of cardiac ischemia. however, research on markers of non-cardiac events has been insufficient. therefore, we investigated the relationship between troponin and myoglobin which are commonly used markers of cardiac ischemia, in n...

introduction: neuroblastoma is the most common extracranial solid tumor in children, accounting for 8% to 10% of all childhood cancers. significantly, autologous transplantation appeared to have the largest impact on survival for the high risk subset of patients, such as those with n-myc amplified metastatic disease diagnosed after age 2 years. patients and methods: this study includes high ris...

vincristine (vcr) as a frequently used antimitotic agent which is commonly prescribed for wide spectrum of neoplasm, causes mixed sensorimotor neuropathy. several evidences show lithium could be a neuroprotective agent, therefore to assess whether a pretreatment and at subtherapeutic dose it could prevent the peripheral neuropathy produced by vcr, rats were treated with vcr 0.1mg/kg i.p. for 3 ...

peripheral blood stem cell transplantation (pbsct) is an effective treatment for hematological malignancies. mobilization of peripheral blood progenitor cells performs in different ways among transplantation centers. forceful mobilization schedules are comprised of growth factor alone, chemotherapy along with growth factor and also, a newly combination of novel agent such as plerixafor with any...

a common cause of peripheral nerve injury is trauma. the positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. in this experiment, the effect of intraperitoneal administration of ubiquinone (coq10) on an acute experimentally sciatic nerve crush was studied in a rat model. forty-five male wistar rats, weighing between 160-180 g were u...