plantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor. Blood 1995; 85:1666-72. 5. Elmaagacli AH, Beelen DW, Becks HW, et al. Molecular studies of chimerism and minimal residual disease after allogeneic peripheral blood progenitor cell or bone marrow transplantation. Bone Marrow Transplant 1996; 18:397-403. 6. Schwartzberg L, Bi...

Acknowledgments: preparation of this manuscript was supported by grants from Dompé Biotec SpA and Amgen Italia SpA, Milan, Italy. Received January 11, 1996; accepted June 4, 1996. T he aim of this review is to define the role of peripheral blood stem cell transplantation for the treatment of multiple myeloma. Therefore, we first review our present knowledge of this disease and then analyze the ...

BACKGROUND Currently available treatment options for decompensated hepatitis B-induced liver cirrhosis are limited and largely ineffective. Recently, stem cell transplantation has emerged as a promising treatment for cirrhosis. The aim of this study was to determine whether autologous peripheral blood stem cell transplantation can improve liver functional reserve in patients with hepatitis B-in...

introduction: despite achievement to complete remission (cr) with current treatments and new multiple chemotherapeutic agents in acute lymphoblastic leukemia (all) patients, the majority of them still relapse during long-term follow-up. the use of post- remission therapy will reduce early relapse in these cases, but the best option is still debatable. patients and methods: in this retrospective...

peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation. Blood 1996; 7:2794-2800. 7. Pavletic ZS, Bishop MR, Tarantolo SR, et al. Hematopoietic recovery after allogeneic blood stem-cell transplantation compared with bone marrow transplantation in patients with hematologic malignancies. J Clin Oncol 199...

Stem cell transplantation is the only curative treatment for a number of haematological and oncological diseases including lymphomas, leukaemias and several solid tumours. Recently the indications for this kind of treatment have been extended into other fields of internal medicine, e.g. autoimmune diseases. For stem cell transplantation it is necessary to have a graft consisting either of autol...

Haematopoietic stem cell transplantation remains the treatment of choice for a variety of benign and malignant blood disorders.1 In this modality Haematopoietic stem cell transplantation is the intravenous infusion of haematopoietic stem and progenitor cells to re-establish marrow function in patients with damaged or defective marrow. The procedure is called Bone Marrow Transplantation (BMT) if...

Allogeneic hematopoietic stem cell transplantation is increasingly used as treatment for patients with life-threatening blood diseases. Its curative potential is largely based on immune-mediated graft-versus-leukemia effects caused by donor T cells contained in the graft. Unfortunately, donor T cells are also the cause of graft-versus-host disease. The vast majority of human leukocyte antigen-m...

Hematopoietic reconstitution after stem cell transplantation requires excessive replicative activity because of the limited number of stem cells that are used for transplantation. Telomere shortening has been detected in hematopoietic cells after bone marrow transplantation. This has been thought to result from excessive replication of the stem cells, with putative concomitant reduction of thei...