OBJECTIVE Precocious puberty is of concern because of the underlying disorders, the short adult stature, and the psychosocial difficulties. This study was carried out in order to evaluate the characteristics of children referred to pediatric endocrinology clinic with diagnosis of precocious puberty. METHODS In a cross-sectional study between February 2007 and September 2009, all of the childr...

Precocious puberty is defined as the appearance of clinical signs before age 8 years in girls and 9 boys. The central origin due to a premature activation hypothalamic-pituitary-gonadal axis from which tumor pathology must be eliminated each case. It distinguished early peripheral independent hypothalamic-pituitary stimulation adrenal or gonadal origin. In boys, precocious most often there high...

We report a 20 month old female patient with diploid-triploid mixoploidy (46,XX/69,XXX) syndrome with hypothyroidism and precocious puberty. The triploid cell line was only expressed in the fibroblast culture and comprised the majority (95%) of the cells. Chromosome analysis of the fetal blood sample and peripheral blood sample were normal. The patient shows typical features of full triploidy (...

Puberty is a complex process that culminates in the acquisition of psychophysical maturity and reproductive capacity. This elaborate fascinating marks end childhood. Behind it lies complex, genetically mediated neuroendocrine mechanism through which gonads are activated thanks to fine balance between central inhibitory stimulating neuromodulators hormones with both peripheral action. The onset ...

hypothalamic hamartoma (hh) is a rare intracranial lesion that usually presents with classic triad of central precocious puberty, gelastic epilepsy, and developmental delay. herein, a 14-year old boy is presented in whom the diagnosis of hh was made by magnetic resonance imaging. while he did not have any complain of precocious puberty, he surprisingly suffered from delay in puberty. the defini...

for all the people living in the community need to be sociable and behave according to the values and norms of society.in the meantime, the girls are given the responsibility of being a mother is very important in the future.. socialization is one of the factors causing early puberty is that many factors are involved in the onset.this study examines the impact of social control and the use of n...

Puberty is often delayed in children with chronic kidney disease. A 5-year-old boy suffering from severe chronic kidney disease due to a mutation in the TCF2 gene presented with a clinical precocious peripheral puberty 3 weeks after introducing cinacalcet and 2 months after introducing lanthanum carbonate. A retrospective measurement of serum sexual and adrenal hormones before the introduction ...

Leydig cell testicular tumors are a rare cause of precocious pseudopuberty in boys. Surgery is the main therapy and shows good overall prognosis. The physical signs of precocious puberty are expected to disappear shortly after surgical removal of the mass. We report two children, 7.5 and 7.7 year-old boys, who underwent testis-sparing surgery for a Leydig cell testicular tumor causing precociou...

hypothyroidism is usually associated with delayed pubertal development but in rare occasions precocious puberty may ensue which is seen in cases of prolonged and untreated hypothyroidism. this is also called the van wyk grumbach syndrome. here we present 4 cases of precocious puberty due to hypothyroidism.