The eukaryotic genome is organized in a manner that allows folding of the genetic material in the confined space of the cell nucleus, while at the same time enabling its physiological function. A major principle of spatial genome organization is the non-random position of genomic loci relative to other loci and to nuclear bodies. The mechanisms that determine the spatial position of a locus, an...

We introduce a heterogeneous connection model for network formation to capture the effect of cost heterogeneity on the structure of efficient networks. In the proposed model, connection costs are assumed to be separable, which means the total connection cost for each agent is uniquely proportional to its degree. For these sets of networks, we provide the analytical solution for the efficient ne...

The power of optogenetics to improve our understanding of neural circuits is clear. Applying optogenetic techniques to humans, however, remains a goal that is yet to be realized. In my laboratory, we have used optogenetics to manipulate activity in selected neurons of the peripheral nervous system, motivated by the desire to use optogenetics to excite muscle in cases of paralysis, inhibit motor...

In recent years, definitions of the nuclear periphery have become increasingly blurred with the realization that nuclear envelope (NE) and nuclear pore complex (NPC) components interact with and influence the behavior of both nuclear and cytoplasmic structures. The Minisymposium on the Nuclear Periphery reflected this evolving outlook by bringing together an eclectic group of researchers workin...