The treatment of onychomycosis is a challenging task because of unique barrier properties of the nail plate which hampers the passage of antifungal drugs in a concentration required to eradicate the deeply seated causative fungi in the nail bed. In present investigation, application of hydroxypropyl-β-cyclodextrin (HP-β-CD) was established as an effective and nail friendly transungual drug perm...

Mixed matrix membranes (MMMs) are attracting significant interest for pervaporation and gas separation applications. To better comprehend the impact of filler particles within polymer matrices, the species permeation mass transport was theoretically studied by numerical simulation using finite differences. The Fick’s second law of diffusion was solved for a three-dimensional MMM to obtain the c...

Separation of amoxicillin from pharmaceutical wastewater by nanofiltration (NF) membrane has been investigated in this study. For this purpose a membrane system including a polyamide spiral wound NF membrane was evaluated for the treatment of amoxicillin wastewater. The effects of operating conditions such as flow rate, pressure and concentration of amoxicillin and COD in the feed, on the effic...

Curcumin is the active component of Curcuma species including C. longa (turmeric). This molecule is well known for its anti-inflammatory effect, which seems to be stronger than that of hydrocortisone. Curcuma species have been used in Asian traditional medicine as topical anti-inflammatory drugs. Curcumin has poor oral bioavailability and its topical application could be of choice, particularly...

We have modeled permeation through anisotropic zeolite membranes with nanoscopic defects that create shortcuts perpendicular to the transmembrane direction (x). We have found that the dimensionless ratio Dy /(kd1y) can be used to estimate whether the shortcuts contribute significantly to the overall flux. Here Dy is the diffusion coefficient for motion in the plane of the membrane, kd is the ra...

A reservoir type transdermal patch for delivery of ketorolac, a potent analgesic agent was studied. The low permeability of skin is the rate-limiting step for delivery of most of the drugs. Studies were carried out to investigate the effect of permeation enhancers on the in vitro permeation of ketorolac across rat skin. The reservoir type transdermal patch was fabricated and the core was filled...

Curcumin is the active component of Curcuma species including C. longa (turmeric). This molecule is well known for its anti-inflammatory effect, which seems to be stronger than that of hydrocortisone. Curcuma species have been used in Asian traditional medicine as topical anti-inflammatory drugs. Curcumin has poor oral bioavailability and its topical application could be of choice, particularly...

Numerical simulation of tritium permeation from breeding zones to the coolant in the helium cooled pebble-bed blanket is performed in this paper. 2D and 3D convection–diffusion models are developed to account for the effects of purge stream convection. Incompressible transient Brinkman model with variable permeability is used in flow calculation, and transient diffusion and convection equations...

This study aims to investigate the applicability of vacuum membrane distillation for concentrating aqueous lithium bromide solution, and to analyze the feasibility of applying vacuum membrane distillation process to the absorption refrigeration system. Hydrophobic polyvinylidene fluoride (PVDF) was adopted as the membrane material, and was made into hollow fiber membrane module. Commercial aque...

In 1955, Alan Hodgkin and Richard Keynes published a study whose intent was to answer a rather technical question, but whose result triggered the modern analysis of ion channel permeation (Hodgkin and Keynes, 1955). They aimed to determine whether the K 1 fluxes in giant axons followed the “Ussing flux ratio criterion,” which was then considered to indicate whether flux through a membrane occur...