Lipid peroxidation is known to be an important factor in the pathologies of many diseases associated with oxidative stress. We assessed the lipid peroxidation induced by the reaction of ferritin with H2O2. When linoleic acid micelles or phosphatidyl choline liposomes were incubated with ferritin and H2O2, lipid peroxidation increased in the presence of ferritin and H2O2 in a concentration-depen...

As a part of our ongoing effort to explore drug induced lipid peroxidation in relation to drug-induced toxicity, this study was undertaken to determine whether nonsteroidal anti-inflammatory drugs (NSAIDs), namely, diclofenac sodium, ibuprofen, flurbiprofen, paracetamol, nimesulide, celecoxib and indomethacin are involved in oxidative/antioxidative processes by determining malondialdehyde (MDA)...

NADPH-cytochrome c reductase in rat liver microsomes was solubilized by bromelain digestion and purified to homogeneity. An antibody preparation obtained by immunization with this enzyme was found to inhibit the NADPHcytochrome c reductase activity of both the purified enzyme and intact microsomes by more than 90%. This antibody also inhibited the NADPH-dependent peroxidation of microsomal lipi...

The effect of alveolar oxygen tension on lung lipid peroxidation during lung ischemia was evaluated by using isolated rat lungs perfused with synthetic medium. After a 5-min equilibration period, global ischemia was produced by discontinuing perfusion while ventilation continued with gas mixtures containing 5% CO2 and a fixed oxygen concentration between 0 and 95%. Lipid peroxidation was assess...

Lipid peroxidation is a highly destructive process, which induces a plethora of alterations in structure and function of cellular membranes. It is involved in number of diseases and poisoning by several toxins. Lipid peroxidation occurs in response to oxidative stress, and a great diversity of aldehydes are formed when lipid hydroperoxides break down in biological systems. Among the aldehydic e...

background: many health problems are related to lifestyle and dietary factors. since ancient times, food additives such as sulfites have been used to preserve foods. diverse effects of sulfites on multiple organs have been reported but its effect on female reproductive organ has not been fully elucidated. the aim of this study was to investigate the effects of sodium metabisulfite (smb) on ovar...

Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease. Here, we studied the effect of oligomeric α-Syn on one of the major markers of oxidative stress, lipid peroxidation, in primary co-cultures of neurons a...