Aim. To develop an animal model of femoral head aseptic necrosis for studying Legg–Calvé–Perthes disease. Materials and Methods. induce the development necrosis, we used Wistar rats (n = 8) which suffered from combined hypoperfusion increased intra-articular pressure in hip joint. Having employed isoflurane anesthesia, performed incision (≈ 3 cm length) on outer surface thigh projection joint t...

This is one of a series of occasional articles highlighting conditions that may be more common than many doctors realise or may be missed at first presentation. The series advisers are Anthony Harnden, professor of primary care, Nuffield Department of Primary Care Health Sciences, University of Oxford, and Richard Lehman, general practitioner, Banbury. To suggest a topic, please email us at pra...

It is now sixty years since Legg (1910), Calve (1910) and Perthes (1910) described the condition of coxa plana, or Perthes’ disease as it is more often called today, thus allowing its differentiation from the much more serious tuberculosis of the hip with which it had formerly been confused. It is ironical to find all these years later that a diagnosis of tuberculosis nowadays entails no more t...

Perthes' disease (Legg-Calvé-Perthes' disease) is relatively common in childhood, affecting 0.8/100.000 children. Late onset Perthes' disease, older than 8 years of age, constitutes about 20% of cases and is known for its aggressive course and poor outcome with chronic hip pain and stiffness. Although containment of the head in the acetabulum is the usual treatment for early cases, its results ...

The Legg-Calve-Perthes disease is an idiopathic avascular necrosis of the hip during early childhood. It is characterized by different stages with the main risk of persisting hip deformation, dysfunction of the joint movement, and the potential for early osteoarthritis. For the evaluation of prognosis and therapy planning patients age and extent of the necrotic area of the epiphysis are importa...

It has recently been postulated that thrombophilia may have a role in the aetiology of Perthes' disease. The published reports, however, remain conflicting. In this study a retrospective analysis of the coagulation parameters was made in 47 patients with Perthes' disease and the results compared with the clinical data. Five patients with Factor V Leiden mutation were found (10.6%) and surprisin...

PURPOSE We assessed the radiographic changes of the acetabulum during the course of Perthes' disease and investigated whether they were associated with femoral head sphericity 5 years after diagnosis. METHODS We studied 123 children with unilateral Perthes' disease, femoral head necrosis more than 50 % and age at diagnosis 6 years or older. Pelvic radiographs were taken at onset, 1 year and 5...

About a hundred years after the first reports about the disease Legg-Calvé-Perthes that Perthes also called, since it is still the main cause of this disease is unknown. Perthes with the loss of femoral head blood flow in growing children, between the ages of 2-13 years is determined and is considered as a vascular disease. The outbreak, one in every 1,200 children younger than 15 years is. 5-4...

Six boys were examined during the second year of life, each with symptoms in one hip. The affected femoral capital epiphysis was smaller or more irregular (or both) than that of the unaffected hip but was neither subluxed nor dislocated. The subsequent radiographs revealed changes similar to those in severe Perthes' disease. Nevertheless, we give reasons for believing that this disorder in boys...