PURPOSE Thermal behavior of some antidiabetic drugs such as pioglitazone hydrochloride (PTZ), rosiglitazone maleate (RGZ), glibenclamide (GBD) and glimepiride (GMP) has been studied. METHODS Thermogravimetric analysis (TGA), derivative thermogravimetry (DTG) and differential thermal analysis (DTA) techniques were used to study the thermal behavior of the drugs under investigation. RESULTS T...

Crystallization processes in the pharmaceutical industry are usually designed to obtain crystals with controlled size, shape, purity, and polymorphic form. Knowledge of the process conditions required to fabricate crystals with controlled characteristics is critical during process development. In this work, continuous crystallization of Ketoconazole, Flufenamic Acid, and L-Glutamic Acid in a no...

The emerging contaminants (ECs) is detected at trace concentration in the discharge of sewage treatment plant (STP) to water bodies indicate incomplete removal during process. presence ECs has a potential impact on ecological and human health associated with long-term ingestion mixture compounds, this includes development resistance pathogenic bacteria, aquatic toxicity, genotoxicity, endocrine...

Executive summary: Bacteria biosynthesize secondary metabolites (collaterals) or in other words a large class of biologically active bio compounds, which have applications in agriculture and the pharmaceutical industry. If knowledge’s about bacilli are more advanced (focused on practical applications has enzymes) in the case of actinomycetes the most information has been obtained from studies o...

21 The study of the occurrence and fate of pharmaceutical compounds in drinking or waste 22 water processes has become very popular in recent years. LC-MS/MS is a powerful 23 analytical tool often used to determine pharmaceutical residues at trace level in water. 24 However, many steps may disrupt the analytical procedure and bias the results. A list of 27 25 environmentally relevant molecules,...

In the pharmaceutical industry, computational methods have gained a major role in the discovery and development of new drugs. Yet, synthesis of the pharmaceutical compounds is among the most crucial steps of drug design along with the life science discoveries complementing it. The review focuses on all the recent developments in the application of computational methods as well as organic synthe...