OBJECTIVES To explore global changes in the prescription of analgesic drugs over time in the international long-term care (LTC) population. DESIGN Systematic review. SETTING We included original research articles in English, published and unpublished, that included number of participants, country and year(s) of data collection, and prescription of analgesics (analgesics not otherwise specif...

Sharon L. Walsh, PhD Center on Drug and Alcohol Research Departments of Behavioral Science, Psychiatry, Pharmacology, and Pharmaceutical Sciences Lexington, KY 40508, USA Email: [email protected] D espite this common warning found in virtually all opioid product package inserts, reports on prescribing practices suggest that all too often this warning is ignored—with grave consequences. Not o...

background: a good proportion of poisoned patients treated at poisoning wards are elderly. this study was designed to evaluate the epidemiologic pattern of acute poisoning in elderly in hamadan, western iran. methods: in this retrospective cross-sectional study, poisoned patients aged 60 years and older treated at department of poisoning of farshchian hospital from march 2008 to march 2013 were...

Background Bioactive peptides prospection is important for biotechnology field as well as a starting point in many research areas, such as: new drugs development and production of genetically modified plants [1]. In general, bioactive peptides have been identified as candidates for the new drugs development because their intrinsic properties concerning some potential activities, like high speci...

The International Classification of Diseases (ICD) and the Diagnostic and Statistical Manual (DSM) are routinely used in diagnosing illicit substance use disorders, but for people taking prescribed opioids they remain controversial. In pain medicine, the concept of "Addiction" is preferred with reduced emphasis on tolerance and withdrawal. This article examines the prevalence and characteristic...

Ohio is experiencing unprecedented loss of life caused by unintentional drug overdoses (1), with illicitly manufactured fentanyl (IMF) emerging as a significant threat to public health (2,3). IMF is structurally similar to pharmaceutical fentanyl, but is produced in clandestine laboratories and includes fentanyl analogs that display wide variability in potency (2); variations in chemical compos...