the pharmacokinetics of cefpirome was investigated in buffalo calves following its single intramuscular (im) administration (10 mg). the peak plasma concentration of cefpirome at 30 min was 9.0 ± 0.5 μg.ml-1, which declined to 0.2 ± 0.1 μg.ml -1 at 24 hrs. the absorption half-life (t1/2ka) and elimination half-life (t1/2 β) were 0.19 ± 0.03 hr and 2.39 ± 0.05 hr, respectively. the area under th...

the pharmacokinetic properties of amoxicillin and clavulanic acid when used alone or in combination may be different and show interaction between these two agents that might decrease the absolute bioavailability of clavulanic acid. in an open, randomized, replicated latin square under fasting condition, pharmacokinetics of new formulations of amoxicillin/clavulanic acid were compared with a ref...

cefquinome sulfate (cs) is a fourth-generation cephalosporin, which has been developed solely for veterinary use. it shows potent antibacterial activity against a broad spectrum of bacterial species. however, cefquinome is susceptible to hydrolysis, which limiting its clinical employment efficacies to some extent. so, in this study, to increase cefquinome sulfate biological half-life, a novel c...

the aim of this study was to characterize the effect of typhoid fever on pharmacokinetic parameters of levofloxacin (lf) and compare the pharmacokinetic parameters of the said antibiotic in healthy human volunteers and patients with typhoid fever. total of 12 subjects were divided into two groups “a” (healthy volunteers) and “b” (typhoid patients). single oral dose of lf 500 mg was given and 5 ...

objective(s) the purpose of this study was assessment of the influence of acute manic phase on the steady state pharmacokinetics of valproic acid (vpa) in bipolar patients in comparison with those of epileptic patients. materials and methods ninteen acutely manic and 25 epileptic patients who fulfilled inclusion and exclusion criteria were entered in this prospective study. blood samples were c...

ôbjective: to investigate the pharmacokinetics (pk) and pk- pharmacodynamic (pd) relationship of methadone in a cohort of outpatients undergoing methadone maintenance treatment (mmt). methods: sixty male patients undergoing mmt with a mean ±sd methadone daily dosage of 58 ± 34 mg were enrolled in this study. â 5-ml blood sample was collected before the daily intake of methadone. âs a pd measure...

a bioequivalence study of two verapamil formulations (generic verapamil tablets and isoptin® tablets) was performed by comparing pharmacokinetic parameters of the parent drug and its major metabolite, norverapamil following a single dose administration of 80 mg verapamil hydrochloride in 22 healthy volunteers according to a randomized, two-period, crossover-design study. moreover, the feasibili...

the pharmacokinetic parameters of ceftazidime, a third generation cephalosporin, were investigated in six buffalo calves after single intravenous (iv) and intramuscular (im) administration at a dose rate of 10 mg/kg body weight. ceftazidime concentrations in plasma and urine were determined by microbiological assay. ceftazidime disposition was best fitted by a two-compartmental and a one-compar...

organophosphate (op) poisoning is one of the most common causes of poisoning in developing countries especially in southeastern asia. poisoning with phosphorus-containing organic chemicals or op compounds can be managed with antidotes like oximes which are potential reactivators of acetylcholinesterase (ache). the efficacy of oxime therapy in op poisoned patients mainly depends upon various fac...