Headaches are common in children and adolescents, and are the most common pain complaint when seeking medical advice. Primary headaches are one of the most common disorders of childhood, with migraine and tension type headache being the most prominent. Treatment strategies for primary headaches vary according to patient’s age, family structure, culture and beliefs, headache diagnosis, and accor...

Molecular imaging using PET provides a unique tool for noninvasively investigating the biochemistry of living organs. The wide range of radiolabeled molecules makes it possible to explore various biochemical, physiologic, and pharmacologic processes in vivo. Because each radiotracer is characterized by its particular kinetic behavior in the human body, the quantification of this behavior is a c...

one of the most common health problems are diseases of the cardiovascular system with a great bulk of disease burden; while a considerable number of cardiac patients undergo cardiac surgery; cardiac surgical procedures with cardiopulmonary bypass (cpb) are nowadays among the top list of surgical procedures. more than half of a century has passed since the introduction of total cardiopulmonary b...

objective: today, medicinal plants are widely used in remedies for several ailments and improvement of human health because of their pharmaceutical properties. this study aimed to document important useful medicinal plants and their medicinal characteristics for treatment of human ailments in the arjan _ parishan protected area in fars province of iran during 2010-2012. materials and methods: d...

drug delivery across the skin is used for several millennia to ease gastrointestinal (gi) ailments in traditional persian medicine (tpm). tpm topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate gi illnesses such as dyspepsia, gastritis, gi ulcers, inflammatory bowel disease, intestinal worms and infections. the aim of the present study i...

Dysfunction of β -glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson's disease occurrence. Pharmacological chaperone design has been used to treat with misfolded protein in related disease, which utilized a small compound to cause protein folding correctly. This study employed the world largest traditional Chinese ...

INTRODUCTION Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher disease (GD), which give rise to significant protein misfolding effects and result in progressive accumulation of glucosyl ceramide. The main treatment for GD is enzyme replacement therapy (ERT). The iminosugar glycosidase inhibitor N-(n-butyl)-1-deoxynojirimycin (miglustat, ...

according to the definition by the national institutes of health of usa, a biological marker (biomarker) is a characteristic that is objectively measured and evaluated, as an indicator of normal biological processes, pathogenic processes or pharmacological responses, to a therapeutic agent. several studies have reported that a decreased regulating gene expression of biotinidase (btd) is associa...

Systemic arterial hypertension is main cause of cerebrovascular events and coronary disease. Therefore, treatment control this disease great importance in public health. Arterial a common that defined as the persistent elevation blood pressure more than 130/80 mm HG by American college cardiology (ACC)/American heart association (AHA), 8th joint national committee (JNC 8) criteria specify≥140/9...