The hydrazone functional group has been extensively studied and used in the context of supramolecular chemistry. Its pervasiveness and versatility can be attributed to its ease of synthesis, modularity, and most importantly unique structural properties, which enable its integration in different applications. This review provides an overview of the utilization of hydrazones in three supramolecul...

In order to understand the role of dipolar interactions vs. H-bonding, a series hydrazones were synthesised from 4-alkoxy-, 3,4-dialkoxy- or 3,4,5-trialkoxybenzaldehydes and phenyl, bromo- nitrophenylhydrazine, respectively. Their mesomorphic properties investigated by differential scanning calorimetry (DSC), polarising optical microscopy (POM), X-ray diffraction (WAXS, SAXS) compared with know...

There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, antibacterial, and antifungal activities. The present study explores antimicrobial activity some new arylidene hydrazide derivatives correlates effect on potency by varying substituents part arylidine hydrazide. Hydrazones possessing an azomethine–NHN=CH- proton constitute important clas...

In the title Schiff base compound, C(12)H(15)N(3)O(2), obtained from a condensation reaction of cyclo-hexa-none and 2-nitro-phenyl-hydrazine, the phenyl-hydrazone group is planar, the largest deviation from the mean plane being 0.0252 (12) Å, and the nitro fragment is twisted slightly with respect to the mean plane, making a dihedral angle of 6.96 (17)°. The cyclo-heaxanone ring displays a chai...

In the title compound, C(14)H(10)FN(3)O, the six- and five-membered rings of the isatin moiety and the six-membered ring of phenyl-hydrazone are nearly planar with r.m.s. deviations of 0.0003, 0.0004 and 0.007 Å, respectively. The dihedral angle between the phenyl ring and the isatin ring system is 6.09 (9)°. The mol-ecular structure is stabilized by a strong intra-molecular N-H⋯O hydrogen bond...

There has been an increasing importance of drug-resistant pathogens in clinical microbiological and antibacterial research. Indoles and hydrazone-type compounds constitute important classes of compounds in the search for effective agents against multidrug-resistant microbial infections. In this study a series of 1-methylindole-3-carboxaldehyde hydrazone derivatives were evaluated for their in v...

In the title compound, C13H11ClN4O3, the phenyl and pyrrolyl ring are linked by an ac-yl-hydrazone (R 2C=N-N-CO-R) group, forming a slightly bent mol-ecule: the dihedral angle subtended by the the phenyl and pyrrolyl rings is 8.46 (12)°. In the crystal, the three-dimensional supra-molecular structure is assembled by N-H⋯O hydrogen bonding. Mol-ecular sheets are formed parallel to (101) in a her...

The asymmetric unit of the title compound, C(21)H(20)N(2), contain two mol-ecules, both of them showing an E configuration of the C=N bond. The dihedral angles between the phenyl rings in the phenyl-hydrazone groups are 86.84 (10) and 84.85 (8)° for the two mol-ecules. Inter-molecular C-H⋯π inter-actions are observed in the crystal structure.

Cycloaddition of nitrile imines 4 generated in situ by the catalytic dehydrogenation of diphenyl hydrazones 3 using Chloramine-T (CAT) as oxidant in glacial acetic acid with enolic form of ethyl acetoacetate 5 afforded Ethyl 3-aryl-5-methyl-1-phenyl-1H-pyrazol-4-carboxylate 6 in 80% yield. The said pyrazoles 6 refluxed with 80% hydrazine hydrate using absolute alcohol as solvent for about 2-3 h...

In the crystal structure of the title compound, C(26)H(22)N(4), the mol-ecule is located on an inversion centre and shows an E configuration with respect to each C=N bond. The dihedral angle between the phenyl rings in the diphenyl-hydrazone group is 83.69 (11)°. These two rings make dihedral angles of 30.53 (15) and 84.53 (16)° with the central N-N=C-C=N-N dihydrazonoethane plane. Inter-molecu...