Histogranin (HN)-like nonpeptides were designed and synthesized using benzimidazole (compound 1) and o-phenylenediamine (compounds 2-7) as scaffolds for the attachment of phenolic hydroxyl and basic guanidino pharmacophoric elements present in HN. The benzimidazole derivative N-5-guanidinopentanamide-(2R)-yl-2-(p-hydroxybenzyl)-5-carboxybenzimidazole (1) and the o-phenylenediamine derivative N-...

This paper reports the synthesis of nitrogen containing heterocyclic compounds such as quinoxalines (5-7), imidazoles (8, 9,10,11), aminothiazole (12), aminooxazole (13), aminoimidazole (14) and benzothiazine (17) from the reaction with unsymmetrical diketone 4, 3 and 4a respectively. The aforementioned compounds with 4-pyridyl,4fluorophenyl groups have different positions in their ring skeleto...

The study reports some preliminary investigations on the template free synthesis of a scantly investigated polyaniline (PANI) derivative-Phenylenediamine (PDA) by template free method in the presence of Oxalic acid (OA) (dopant), using Ammonium Persulfate as oxidant. Polymerization of Phenylenediamine (PDA) was confirmed by the FT-IR as well as UV–visible studies. The morphology of Phenylenedia...

Investigations on the transfer of the ligand, imidazole (HIm), between two covalently linked redox centres--zinc porphyrin and phenylenediamine (PD)--and the influence of the length of the linker are reported. Since the binding affinity of the ligand with zinc porphyrin is different from that of the ligand with the phenylenediamine moiety, the transfer of the ligand could be electrochemically c...

The Cosmetic Ingredient Review Expert Panel (CIR Panel) reviewed the safety of hydroxypropyl bis(N-Hydroxyethyl-p-Phenylenediamine) HCl, which functions as an oxidative hair dye ingredient. The Panel considered relevant animal and human data provided in this safety assessment and concluded that hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) HCl is safe for use in oxidative hair dye formul...

The carcinogenicity of 23 phenylenediamines and related compounds was reviewed. An extensive analysis of the methods used indicated that the bioassays were conducted well. The data suggest that the carcinogenicity of 4-substituted 1,3-phenylenediamines is reduced substantially or eliminated completely by oxidation of one or both amine groups or by N-substitution. Oxidation of a methyl substitue...

Ferricyanide-containing liposomes were used as a system to compare the electron- and proton-translocating properties of six redox reagents commonly used as electron donors for biochemical systems. The effects of different ionophore combinations on the ferricyanide-reduction rate were generally consistent with the expected proton- and electron-translocating properties of the mediators. The trans...

A bioassay for the possible carcinogenicity of 2-nitro-p-phenylenediamine was conducted using Fischer 344 rats and B6C3F1 mice. 2-Nitro-p-phenylenediamine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. Twenty animals of each sex and species were placed on test as controls. The high and low dietary concentrations of 2-ni...

Optimum reaction conditions were evaluated for assay of serum ceruloplasmm by measurement of its p-phenylenediamine oxidase activity. The pH optima of p-phenylenediamine oxidase activities of human and rat ceruloplasmins were 5.45 and 5.2, respectively. The p-phenylenediamine oxidase activity of rat ceruloplasmin was markedly inhibited by phosphate (0.1 mol/Iiter), that of human ceruloplasmin o...