نتایج جستجو برای: phosphodiesterase 4
تعداد نتایج: 1312167 فیلتر نتایج به سال:
To the Editor: We read with great interest the December 1, 2008, article by Goldhoff et al. (1) on the role of cyclic AMP phosphodiesterase-4 (PDE4) in brain tumor growth. The authors found that PDE4 is expressed in human brain tumors of glial and neuronal lineage (glioblastoma, medulloblastoma, ependymoma, and meningioma). In addition, overexpression of PDE4A1, a brain-specific isoform of PDE4...
Asthma is a heterogeneous disease characterized by chronic inflammation of the airways induced reversible obstruction resulting in mortality and morbidity. Roflumilast second-generation selective inhibitor phosphodiesterase-4 targeting PDE type 4 isoenzymes, disturbing breakdown cyclic AMP (cAMP) reducing inflammation. However, it has not been recommended for asthma patients because insufficien...
1. Both the Ca(2+)-pump ATPase and the polyphosphoinositide phosphodiesterase of the erythrocyte membrane can, when assayed under appropriate conditions, be activated by Ca(2+) in the micromolar range. We have therefore compared the mechanisms and affinities for Ca(2+) activation of the two enzymes in human erythrocyte membranes, to see whether the polyphosphoinositide phosphodiesterase would b...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید