Peripheral blood is an accessible adult stem cell source for both basic and applied research including clinical applications. Peripheral blood mononuclear cells (PBMCs) were reported to possess multipotent progenitor cell populations and has the potential to differentiate into blood cells, endothelial cells, hepatocytes, cardiomyogenic cells, smooth muscle cells, osteoblasts and so on. They can...

clude some 500 species and are widespread in temperate and tropical climates. Phyllanthus species have attracted the attention of researchers for their hepatoprotective properties; an aqueous extract of Phyllanthus amarus was demonstrated to exert antihepatitis B virus effects to varying degrees. In 2003, various constituents isolated from Phyllanthus species were screened for anti-human hepati...

Various doses of the aqueous extract of Phyllanthus amarus (AEPA) were investigated for analgesic and anti-inflammatory activities using both thermal and chemical models of pain assessment in rats. The extract caused a significant (P < 0.05) dose related increase inhibition of the carrageenan-induced paw oedema in the rats. The inhibition produced by 200 mg/kg AEPA (70.20%) was significantly hi...

OBJECTIVE To determine the antioxidant activity and cytotoxicity of Phyllanthus virgatus crude extract compared to Phyllanthus amarus. METHODS Phenolic contents of the hydromethanolic extracts were measured using Folin-Ciocalteu reagent. Antioxidant activity was evaluated by the 2,2-diphenyl-1-picrylhydrazyl hydrate free radical scavenging and antilipid peroxidation assays. Cytotoxicity on hu...

Present investigation was aimed at formulation, characterization and evaluation of phytosomal complex tablets for sustained delivery of Phyllanthus amarus complex. Phyllanthin, one of the active lignin present in this plant species was isolated from the aerial parts, by silica gel column chromatography employing gradient elution with hexane–ethyl acetate solvent mixture. It was obtained in high...

A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective ...

In spite of considerable efforts to identify effective treatments for urolithiasis, this is a goal yet to be achieved. This review summarizes experimental and clinical data evaluating the effect of the plant Phyllanthus niruri, a plant with worldwide distribution, as a potential agent to prevent and/or to treat urolithiasis The review is based on data from the literature and on the results obta...

Phyllanthus has been widely used in traditional medicine as an antipyretic, a diuretic, and to treat liver diseases and viral infections. Correct genotype identification of medicinal plant material remains important for the botanical drug industry. Limitations of chemical and morphological approaches for authentication have generated the need for newer methods in quality control of botanicals. ...

The antimicrobial efficiency of Phyllanthus amarus Schum. and Thonn, medicinal plants (leaf extracts), was examined using ethanol and chloroform as solvents and tested against human pathogens ; Staphylococcus aureus, Escherichia coli, and Candida albican, using the agar well-diffusion method and minimum inhibitory concentration. The result of the phytochemical analysis of the plant showed that ...