Objective(s): Since bisphenol A (BPA) induces bone loss and phytoestrogens enhance the osteoblastogenesis by binding to the non-classical and classical oestrogen receptors, respectively, the present study was aimed to observe the osteoprotective effect of phytoestrogens on BPA-induced osteoblasts in hFOB 1.19 cells.Materials and Methods:...

Accumulated evidence from epidemiological, clinical, and laboratory studies have supported the important role of estrogens on skin physiology. Estrogen therapy has been demonstrated as a therapy for the signs of ageing related to estrogen deficiency in menopausal women. Unlike cosmetic products, estrogens cannot be used as therapy for skin-ageing in all women due to their potencies and ability ...

BACKGROUND Use of food supplements-containing phytoestrogens among postmenopausal women is rapidly increasing. Although phytoestrogens are often perceived as safe, evidence for overall positive risk-benefit profile is still inconclusive. The chance to buy them by user's initiative does not facilitate surveys on their prevalence and pattern of use. The aim of this study was to describe the patte...

Phytoestrogens are present in certain edible plants being most abundant in soy; they are structurally and functionally analogous to the estrogens. Phytoestrogens have been applied for compensation of hormone deficiency in the menopause. At the same time, soy products are used in infant food and other foodstuffs. Furthermore, soy is applied as animal fodder, so that residual phytoestrogens and t...

Phytoestrogens are polyphenolic compounds that occur ubiquitously in food of plant origin and they have a variety of biological effects in numerous animal cell systems in vivo as well in vitro. Results of studies conducted on animals have shown that effects of phytoestrogens vary depending on species, sex, routes of administration, dose and exposure time. This review summarizes the results of o...

The present study aims to optimize the treatment in menopause by replacing pharmaceutical preparations containing estroprogestatives with products containing phytoestrogens, with less contraindications and side effects. The objective of the study was to compare the in vivo effects of hormone therapy administered in small doses, with that of soy phytoestrogens, in the evolution of urogenital sym...

BACKGROUND Subchronic administration of the potent pharmaceutical estrogen diethylstilbestrol (DES) to female Fischer 344 (F344) rats induces growth of large, hemorrhagic pituitaries that progress to tumors. Phytoestrogens (dietary plant estrogens) are hypothesized to be potential tumor inhibitors in tissues prone to estrogen-induced cancers, and have been suggested as "safer" estrogen replacem...

Phytoestrogens, plant food components with estrogen-like biological properties, are hypothesized to contribute to the 5-fold lower breast cancer incidence in Asian compared with Western countries (1). Isoflavones comprise the phytoestrogens most abundant in soy, the traditional staple food in Asia, and a recent meta-analysis concluded that there was a slight reduction in premenopausal breast ca...

Epidemiologic data illustrate strong associations between diets high in foods containing phytoestrogens and a reduction in coronary heart disease (CHD), breast and other cancers, and menopausal symptoms. However, controlled clinical trials that encourage health care providers to endorse phytoestrogens as an alternative to conventional hormone replacement therapy (HRT) in postmenopausal women ar...

Phytoestrogens are natural constituents of our diets that have been suggested to protect against hormone-dependent breast cancer. Some of the diverse effects of these compounds may be attributed to ligand-dependent differences in their interaction with oestrogen receptor sub-classes. However, phytoestrogens can also inhibit enzymes that are involved in the generation and removal of endogenous s...