Background: Although various surface disinfectants have been introduced, most of them are toxic. The use of natural antimicrobial agent e.g. phytol, extracted from Leptadenia pyrotechnica is a new strategy. The aim of this study was to evaluate the antimicrobial activity, toxicity, and stability of phytol. Methods: The serial concentrations of phytol were prepared, and separately incubated with...

Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and oxidative stress. The anti-inflammatory activities of phytol were assessed by me...

BACKGROUND Vaccine efficacy depends significantly on the use of appropriate adjuvant(s) in the formulation. Phytol, a dietary diterpene alcohol, is similar in structure to naturally occurring isoprenoid adjuvants; but little is known of its adjuvanticity. In this report, we describe the relative safety and efficacy of phytol and its hydrogenated derivative PHIS-01 compared to commercial adjuvan...

background: although various surface disinfectants have been introduced, most of them are toxic. the use of natural antimicrobial agent e.g. phytol, extracted from leptadenia pyrotechnica is a new strategy. the aim of this study was to evaluate the antimicrobial activity, toxicity, and stability of phytol. methods: the serial concentrations of phytol were prepared, and separately incubated with...

Patients suffering from Refsum's disease show mutations in the enzyme necessary for the degradation of phytanic acid. Accumulation of this tetramethyl-branched fatty acid in inner organs leads to severe neurological and cardiac dysfunctions which can even result in death. Thus, patients with Refsum's disease have to follow a specific diet resigning foods with high levels of phytanic acid and tr...

Phytol is a branched-chain fatty alcohol that is a naturally occurring precursor of phytanic acid, a fatty acid involved in the pathogenesis of Refsum disease. The conversion of phytol into phytanic acid is generally believed to take place via three enzymatic steps that involve 1) oxidation to its aldehyde, 2) further oxidation to phytenic acid, and 3) reduction of the double bond at the 2,3 po...

Herbicidal Action of Aminotriazol, Wheat and Oat Seedlings, Chlorophyll, Phytol, Geranylgeraniol, Dihydrogeranylgeraniol, Tetrahydrogeranylgeraniol Treatment of wheat caryops with 3-amino-l,2,4-triazol followed by dark germination leads to phytol deficiency (based on the chlorophyll content) during the subsequent greening process in the light. The analysis of the pigment fraction reveales the p...

Phytol-U-14C was adsorbed on algae and ingested in this form by zooplanktonic copepods (two species of Culunus). The lipids of these animals were analyzed after 48 hr and found to contain radioactive pristane and radioactive phytanic acid. The conversion of phytol to pristane by the copepods is interpreted as a likely biological source of pristane in nature.

BACKGROUND Adjuvants are known to significantly enhance vaccine efficacy. However, commercial adjuvants often have limited use because of toxicity in humans. The objective of this study was to determine the comparative effectiveness of a diterpene alcohol, phytol and its hydrogenated derivative PHIS-01, relative to incomplete Freund's adjuvant (IFA), a commonly used adjuvant in augmenting prote...

Branched-chain fatty acids (such as phytanic and pristanic acid) are ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor alpha (PPARalpha) in vitro. To investigate the effects of these physiological compounds in vivo, wild-type and PPARalpha-deficient (PPARalpha-/-) mice were fed a phytol-enriched diet. This resulted in increased plasma and liver levels of the ph...