Canine papillomaviruses (CPVs) have been identified in various benign and malignant neoplastic skin disorders. The most frequent manifestations of CPV infections are classical warts and pigmented plaques. Although the etiology of canine oral papillomatosis is well established, knowledge about CPVs role in the development of pigmented plaques remains vague. Indeed, as CPV DNA may frequently be f...

We performed epi-mode pump-probe imaging of melanin in excised human pigmented lesions and both hemoglobin and melanin in live xenograft mouse melanoma models to depths greater than 100 µm. Eumelanin and pheomelanin images, which have been previously demonstrated to differentiate melanoma from benign lesions, were acquired at the dermal-epidermal junction with cellular resolution and modest opt...

HAART: highly active antiretroviral therapy INTRODUCTION Oral melanoma accounts for approximately 1% of all melanomas. In contrast to cutaneous melanoma, the risk factors for development of oral melanoma are largely unknown. Immunosuppressive states, including HIV infection and iatrogenic immunosuppression, are associated with an increased risk of melanoma development. Pregnancy has not been fo...

OBJECTIVES To describe the relevant morphologic features and to create a simple diagnostic method for pigmented basal cell carcinoma (BCC) using in vivo cutaneous surface microscopy (ie, dermoscopy, dermatoscopy, or oil epiluminescence microscopy). DESIGN Pigmented skin lesions were photographed in vivo using immersion oil (surface microscopy). All pigmented skin lesions were excised and revi...

Although frequently performed, laser removal of pigmented lesions still contains certain controversial issues. Epidermal pigmented lesions include solar lentigines, ephelides, café au lait macules and seborrheic keratoses. Dermal lesions include melanocytic nevi, blue nevi, drug induced hyperpigmentation and nevus of Ota and Ito. Some lesions exhibit both an epidermal and dermal component like ...

Twenty years of laser dermatology has resulted in current technology which allows variable spot sizes, different wavelengths, and a variety of effective cooling devices. These developments have made the treatment of cutaneous pigmented and vascular lesions safe and efficacious by targeting selected chromophores while minimizing damage to the surrounding tissue. Vascular lesions are targeted by ...

ADVANTAGESOVEREXISTING TECHNOLOGY Early detection of melanoma is the single most promising strategy to cut mortality rates of this disorder.1 Thus far, most skin disease is diagnosed by simple visual inspection and biopsy. Two factors directly influence clinical practice and patient management: first, the ability to identify lesions correctly that have the potential to be melanoma; and second, ...

moved owing to a clinical suspicion of malignancy, we collected the clinical differential diagnoses for all pigmented lesions biopsied. We defined clinically suspect lesions as those for which the study dermatologist’s differential diagnosis indicated melanoma and/or dysplastic nevus on the pathology requisition form. In this way, lesions removed for cosmetic purposes were excluded from the BMR...