Background: Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are prescribed widely for the treatment of depression, anxiety disorders and other psychiatric disorders. Although antidepressants are considered as a safety drug category but unexpected cardiovascular events have been reported as the most serious complications. The aim of this s...

PURPOSE The purpose of this study was to investigate whether antidepressants are more effective than placebo in the primary care setting, and whether there are differences between substance classes regarding efficacy and acceptability. METHODS We conducted literature searches in MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and PsycINFO up to December 2013. Random...

Background Selective serotonin reuptake inhibitors (SSRIs) have been observed to drive programmed cell death in Burkitt lymphoma cells. Accordingly, they were proposed as a new modality in the treatment of Burkitt lymphoma. However, they induce apoptosis with little if any appreciable selectivity. Actually, the selectivity appears to be so low that SSRIs can also kill protozoa (such as Trichomo...

B. Understand the indications, contraindications, efficacy, use, drug interactions, and side effects of classical and newer or alternative antidepressants for treating comorbid mood or anxiety disorders in patients with pain. This would include the use of first-generation agents (e.g., tricyclics, including nortriptyline and desipramine, and monoamine oxidase inhibitors, including phenelzine), ...

Referências 1. Rowe DL. Off-label prescription of quetiapine in psychiatric disorders. Expert Rev Neurother. 2007;7(7):841-52. 2. Rachid F, Bertschy G, Bondolfi G, Aubry JM. Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases. J Clin Psychiatry. 2004;65(11):1537-45. 3. McIntyre A, Gendron A, McIntyre A. Quetiapine reduces residual depressive ...

Panic disorder is a chronic and disabling condition that is often accompanied by other psychiatric and medical conditions. The serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have been used effectively with panic disorder (PD) and conditions in which panic attacks frequently occur. Escitalopram is the most selective SSRI and a variety of evidence s...

It is known that newer antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs), provide advantages in tolerability over antidepressants such as the tricyclics. However, even within the SSRI class, differences in efficacy or tolerability exist between the individual drugs. Among the three most widely prescribed SSRIs are paroxetine, sertraline, and escitalopram. Escitalopram...

We investigate how the prescribing behavior of physicians reacts to scientific information and recommendations released by public authorities. Taking example antidepressant drugs, we use French panel data on exhaustive prescriptions made a representative sample general practitioners more than 110,000 depressed patients between 2000 2008. New results revealing an increase in suicidal thinking am...

BACKGROUND Antidepressants can impair sexual arousal. Exercise increases genital arousal in healthy women, likely due to increasing sympathetic nervous system (SNS) activity. PURPOSE Test if exercise increases genital arousal in women taking antidepressants, including selective serotonin reuptake inhibitors (SSRIs), which suppress SNS activity, and selective serotonin and norepinephrine reupt...

Inadequate treatment response and emotional blunting are common challenges with selective serotonin reuptake inhibitors/serotonin-noradrenaline inhibitors (SSRIs/SNRIs) for major depressive disorder (MDD). We investigated the effectiveness of vortioxetine on in patients partial to SSRIs/SNRIs. Patients MDD who experienced a SSRI/SNRI monotherapy at adequate dose ?6 weeks were switched 8 10-20 m...