Appropriate fetal growth relies upon adequate placental nutrient transfer. Birthweight:placental weight ratio (BW:PW ratio) is often used as a proxy for placental efficiency, defined as the grams of fetus produced per gram placenta. An elevated BW:PW ratio in an appropriately grown fetus (small placenta) is assumed to be due to up-regulated placental nutrient transfer capacity i.e., a higher nu...

The intrauterine existence of fetus solely depends on one organ “The Placenta”. Placenta is a vital organ playing central role in pregnancy. It maintains pregnancy and promotes normal fetal development and serves as a major organ for transfer of essential elements between mother and fetus. 1 It has a significant role in health of the fetus because it is the sole source of nutrients for the fetu...

OBJECTIVES Placental antibody transfer is impaired in the context of HIV infection, which may render HIV-exposed, uninfected infants vulnerable to group B Streptococcus (GBS) disease. The GBS antibody response predominately consists of immunoglobulin G2 (IgG2) antibody. Thus we determined whether concentration and placental transfer of anti-GBS antibody subclasses was altered in HIV-infected co...

We investigated the in vitro transfer of three parathyroid hormone (PTH) fragments (amino acids 35-84, 44-68 and 65-84) through human placenta at term. The perfused and transferred fragments were measured radioimmunologically and identified by three different methods: high-pressure-liquid chromatography (HPLC), preparative flat-bed electrofocusing (PEGG), and gel filtration (GF). The study demo...

Information derived from animal investigations using labelled thtty acid infusions and measurements of the fatty acid concentrations found in the various fractions i n maternal and foetal umbilical artery and venous blood and tissues have shown that the net flux of fatty acid from mother t o foetus across the placenta varies greatly from species to species. In general, in those species with mat...

The concentrations of cefotiam dihydrochloride (CTM) in maternal and fetal blood and in amniotic fluid were determined by bioassay in 38 women at parturition. With an intravenous infusion of 1 g of CTM, the decline in concentration of CTM in maternal blood was biphasic; CTM was not detectable at 6 h after administration. Peak levels of CTM in umbilical cord blood (13.0 to 23.9 micrograms/ml) w...