OBJECTIVE The purposes of this study were to (1) evaluate correlations among platelet, leukocyte, growth factor, and cytokine concentrations in canine platelet-rich plasmas (PRPs) produced from five different canine PRP-concentrating systems and (2) compare the effects of different activation protocols on platelet activation and growth factor release from one of these PRPs. METHODS PRP was ma...

List of Abbreviations: EGP: Epidermal Growth Factor; FBS: Fetal Bovine Serum; FGF-2: Fibroblast Growth Factor-2; HGF-1: Hepatocyte Growth Factor-1; HSCs: Hematopoietic Stem Cells; IGF-1: Insulin-like Growth Factor; IL: Interleukin; MSCs: Mesenchymal Stem Cells; PBSCs: Peripheral Blood Stem Cells; PDGF: Platelet Derived Growth Factor; PRP: Platelet Rich Plasma; TGF-β: Transforming Growth Factor-...

The effects of platelet-derived growth factor and plasma components on saturation density in cultures of 3T3 cells were investigated. Both of these components of whole blood serum affect saturation density; however, when 3T3 cells become quiescent at high density in medium containing whole blood serum, only platelet-derived growth factor and fresh whole blood serum are capable of stimulating pr...

multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. many studies have shown that inflammation causing neuronal demyelination. ms is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. platelet activating fact...

Integrins and growth factor receptors act synergistically to modulate cellular functions. The αvβ3 integrin and the platelet-derived growth factor receptor have both been shown to play a positive role in cell migration. We show here that a platelet derived growth factor-BB gradient stimulated migration of rat microvascular endothelial cells on vitronectin (9.2-fold increase compared to resting ...

Abbreviations: A0: Cross-Section; BDNF: Brain Derived Growth Factor; BMP: Bone Morphogenetic Proteins: CGF: Concentrated Growth Factors: EGM: Endothelial Growth Medium:EBM-2: Endothelial Basal Medium 2; F: Load; FGM: Fibroblast Growth Medium; FBM: Fibroblast Basal Medium; H: Height; H0: Initial Height; HE: Hematoxylin And Eosin Staining; HOB: Human Osteoblasts; HRP: Horseradish Peroxidase; HUVE...